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Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy.

Publication ,  Journal Article
Ku, CW; Zhang, X; Zhang, VR-Y; Allen, JC; Tan, NS; Østbye, T; Tan, TC
Published in: Sci Rep
February 18, 2021

Progesterone is a steroid hormone that is critical for implantation and maintenance of pregnancy, and low levels are associated with higher miscarriage risk. However, little is known about its trajectory during early pregnancy. We sought to determine the gestational age-specific normative values of serum progesterone on a week-by-week basis, and its associated maternal and fetal factors, during the first trimester of a viable low-risk pregnancy. A cross-sectional study was conducted at KK Women's and Children's Hospital from 2013 to 2018. 590 women with a single viable intrauterine low-risk pregnancy, between gestational weeks 5 and 12, were recruited. Serum progesterone showed an increasing trend during the first trimester, with a transient decline between gestational weeks 6-8, corresponding to the luteal-placental shift. Lowest levels were seen at week 7. Maternal age, BMI, parity, gestational age and outcome of pregnancy at 16 weeks' gestation were found to be associated with progesterone levels. Normative values of serum progesterone for low-risk pregnancies would form the basis for future work on pathological levels of serum progesterone that may increase risk of miscarriage. Larger studies are required to validate these normative values, and personalize them to account for maternal age, BMI, parity and gestational age.

Duke Scholars

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

February 18, 2021

Volume

11

Issue

1

Start / End Page

4161

Location

England

Related Subject Headings

  • Progesterone
  • Pregnancy Trimester, First
  • Pregnancy
  • Placenta
  • Male
  • Humans
  • Gestational Age
  • Female
  • Cross-Sectional Studies
  • Adult
 

Citation

APA
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ICMJE
MLA
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Ku, C. W., Zhang, X., Zhang, V.-Y., Allen, J. C., Tan, N. S., Østbye, T., & Tan, T. C. (2021). Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy. Sci Rep, 11(1), 4161. https://doi.org/10.1038/s41598-021-83805-w
Ku, Chee Wai, Xiaoxuan Zhang, Valencia Ru-Yan Zhang, John Carson Allen, Nguan Soon Tan, Truls Østbye, and Thiam Chye Tan. “Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy.Sci Rep 11, no. 1 (February 18, 2021): 4161. https://doi.org/10.1038/s41598-021-83805-w.
Ku CW, Zhang X, Zhang VR-Y, Allen JC, Tan NS, Østbye T, et al. Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy. Sci Rep. 2021 Feb 18;11(1):4161.
Ku, Chee Wai, et al. “Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy.Sci Rep, vol. 11, no. 1, Feb. 2021, p. 4161. Pubmed, doi:10.1038/s41598-021-83805-w.
Ku CW, Zhang X, Zhang VR-Y, Allen JC, Tan NS, Østbye T, Tan TC. Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy. Sci Rep. 2021 Feb 18;11(1):4161.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

February 18, 2021

Volume

11

Issue

1

Start / End Page

4161

Location

England

Related Subject Headings

  • Progesterone
  • Pregnancy Trimester, First
  • Pregnancy
  • Placenta
  • Male
  • Humans
  • Gestational Age
  • Female
  • Cross-Sectional Studies
  • Adult