The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets.
The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets.
Duke Scholars
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Related Subject Headings
- beta Catenin
- Wnt Signaling Pathway
- Mice
- Male
- Islets of Langerhans
- Genes, myc
- Frizzled Receptors
- Female
- Cell Proliferation
- Cell Movement
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Location
Related Subject Headings
- beta Catenin
- Wnt Signaling Pathway
- Mice
- Male
- Islets of Langerhans
- Genes, myc
- Frizzled Receptors
- Female
- Cell Proliferation
- Cell Movement