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Rationale and design of the Kidney Precision Medicine Project.

Publication ,  Journal Article
de Boer, IH; Alpers, CE; Azeloglu, EU; Balis, UGJ; Barasch, JM; Barisoni, L; Blank, KN; Bomback, AS; Brown, K; Dagher, PC; Dighe, AL; Gaut, JP ...
Published in: Kidney Int
March 2021

Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The Kidney Precision Medicine Project aims to ethically and safely obtain kidney biopsies from participants with CKD or AKI, create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes. An additional aim is to identify critical cells, pathways, and targets for novel therapies and preventive strategies. This project is a multicenter prospective cohort study of adults with CKD or AKI who undergo a protocol kidney biopsy for research purposes. This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD attributed to diabetes or hypertension and AKI attributed to ischemic and toxic injuries. Reference kidney tissues (for example, living-donor kidney biopsies) will also be evaluated. Traditional and digital pathology will be combined with transcriptomic, proteomic, and metabolomic analysis of the kidney tissue as well as deep clinical phenotyping for supervised and unsupervised subgroup analysis and systems biology analysis. Participants will be followed prospectively for 10 years to ascertain clinical outcomes. Cell types, locations, and functions will be characterized in health and disease in an open, searchable, online kidney tissue atlas. All data from the Kidney Precision Medicine Project will be made readily available for broad use by scientists, clinicians, and patients.

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Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

March 2021

Volume

99

Issue

3

Start / End Page

498 / 510

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Renal Insufficiency, Chronic
  • Proteomics
  • Prospective Studies
  • Precision Medicine
  • Kidney
  • Humans
  • Adult
  • Acute Kidney Injury
  • 3202 Clinical sciences
 

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de Boer, I. H., Alpers, C. E., Azeloglu, E. U., Balis, U. G. J., Barasch, J. M., Barisoni, L., … Kidney Precision Medicine Project, . (2021). Rationale and design of the Kidney Precision Medicine Project. Kidney Int, 99(3), 498–510. https://doi.org/10.1016/j.kint.2020.08.039
Boer, Ian H. de, Charles E. Alpers, Evren U. Azeloglu, Ulysses G. J. Balis, Jonathan M. Barasch, Laura Barisoni, Kristina N. Blank, et al. “Rationale and design of the Kidney Precision Medicine Project.Kidney Int 99, no. 3 (March 2021): 498–510. https://doi.org/10.1016/j.kint.2020.08.039.
de Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, et al. Rationale and design of the Kidney Precision Medicine Project. Kidney Int. 2021 Mar;99(3):498–510.
de Boer, Ian H., et al. “Rationale and design of the Kidney Precision Medicine Project.Kidney Int, vol. 99, no. 3, Mar. 2021, pp. 498–510. Pubmed, doi:10.1016/j.kint.2020.08.039.
de Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, Blank KN, Bomback AS, Brown K, Dagher PC, Dighe AL, Eadon MT, El-Achkar TM, Gaut JP, Hacohen N, He Y, Hodgin JB, Jain S, Kellum JA, Kiryluk K, Knight R, Laszik ZG, Lienczewski C, Mariani LH, McClelland RL, Menez S, Moledina DG, Mooney SD, O’Toole JF, Palevsky PM, Parikh CR, Poggio ED, Rosas SE, Rosengart MR, Sarwal MM, Schaub JA, Sedor JR, Sharma K, Steck B, Toto RD, Troyanskaya OG, Tuttle KR, Vazquez MA, Waikar SS, Williams K, Wilson FP, Zhang K, Iyengar R, Kretzler M, Himmelfarb J, Kidney Precision Medicine Project. Rationale and design of the Kidney Precision Medicine Project. Kidney Int. 2021 Mar;99(3):498–510.
Journal cover image

Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

March 2021

Volume

99

Issue

3

Start / End Page

498 / 510

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Renal Insufficiency, Chronic
  • Proteomics
  • Prospective Studies
  • Precision Medicine
  • Kidney
  • Humans
  • Adult
  • Acute Kidney Injury
  • 3202 Clinical sciences