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Validity and Responsiveness of the Patient-reported Outcomes Measurement Information System in Children With Ulcerative Colitis.

Publication ,  Journal Article
Brenner, EJ; Long, MD; Mann, CM; Lin, L; Chen, W; Reyes, C; Bahnson, KM; Reeve, BB; Kappelman, MD
Published in: J Pediatr Gastroenterol Nutr
July 1, 2021

OBJECTIVES: Patient-reported outcome measures allow children to directly report on their health and well-being. We assessed the construct validity and responsiveness of the Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric measures in children and adolescents with ulcerative colitis (UC). METHODS: Through the Inflammatory Bowel Disease Partners Kids & Teens' Internet-based cohort, children with UC reported symptoms related to disease activity (Pediatric Ulcerative Colitis Activity Index), IMPACT-III health-related quality of life measure, and 5 PROMIS Pediatric measures (anxiety, depressive symptoms, pain interference, fatigue, and peer relationships). We included participants aged 9 to 17 years and conducted cross-sectional and longitudinal, mixed-linear regression analyses to examine the extent to which PROMIS Pediatric scores are associated with and respond to changes in Pediatric Ulcerative Colitis Activity Index and IMPACT-III. RESULTS: We evaluated 91 participants with UC (mean age 13 years, 57% girls). Better PROMIS Pediatric scores were associated with lower disease activity, in both cross-sectional and longitudinal analyses. For a change from moderate/severe to remission, observed effect estimates were -5.1 points for anxiety, -5.0 for depressive symptoms, -14.7 for pain interference, -13.7 for fatigue, and 5.3 for peer relationships (P < 0.05 for all domains). Better PROMIS Pediatric scores were associated with improved IMPACT-III scores (P values <0.01), and changes in scores were moderately correlated with changes in IMPACT-III over time (adjusted P values <0.01). CONCLUSIONS: This study provides evidence for the construct validity and longitudinal responsiveness of the PROMIS Pediatric measures in pediatric patients with UC, thus supporting their use in clinical research and patient care.

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Published In

J Pediatr Gastroenterol Nutr

DOI

EISSN

1536-4801

Publication Date

July 1, 2021

Volume

73

Issue

1

Start / End Page

67 / 72

Location

United States

Related Subject Headings

  • Quality of Life
  • Patient Reported Outcome Measures
  • Male
  • Information Systems
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Cross-Sectional Studies
  • Colitis, Ulcerative
  • Child
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Brenner, E. J., Long, M. D., Mann, C. M., Lin, L., Chen, W., Reyes, C., … Kappelman, M. D. (2021). Validity and Responsiveness of the Patient-reported Outcomes Measurement Information System in Children With Ulcerative Colitis. J Pediatr Gastroenterol Nutr, 73(1), 67–72. https://doi.org/10.1097/MPG.0000000000003101
Brenner, Erica J., Millie D. Long, Courtney M. Mann, Li Lin, Wenli Chen, Camila Reyes, Kirsten M. Bahnson, Bryce B. Reeve, and Michael D. Kappelman. “Validity and Responsiveness of the Patient-reported Outcomes Measurement Information System in Children With Ulcerative Colitis.J Pediatr Gastroenterol Nutr 73, no. 1 (July 1, 2021): 67–72. https://doi.org/10.1097/MPG.0000000000003101.
Brenner EJ, Long MD, Mann CM, Lin L, Chen W, Reyes C, et al. Validity and Responsiveness of the Patient-reported Outcomes Measurement Information System in Children With Ulcerative Colitis. J Pediatr Gastroenterol Nutr. 2021 Jul 1;73(1):67–72.
Brenner, Erica J., et al. “Validity and Responsiveness of the Patient-reported Outcomes Measurement Information System in Children With Ulcerative Colitis.J Pediatr Gastroenterol Nutr, vol. 73, no. 1, July 2021, pp. 67–72. Pubmed, doi:10.1097/MPG.0000000000003101.
Brenner EJ, Long MD, Mann CM, Lin L, Chen W, Reyes C, Bahnson KM, Reeve BB, Kappelman MD. Validity and Responsiveness of the Patient-reported Outcomes Measurement Information System in Children With Ulcerative Colitis. J Pediatr Gastroenterol Nutr. 2021 Jul 1;73(1):67–72.

Published In

J Pediatr Gastroenterol Nutr

DOI

EISSN

1536-4801

Publication Date

July 1, 2021

Volume

73

Issue

1

Start / End Page

67 / 72

Location

United States

Related Subject Headings

  • Quality of Life
  • Patient Reported Outcome Measures
  • Male
  • Information Systems
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Cross-Sectional Studies
  • Colitis, Ulcerative
  • Child