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Vitamin D Supplementation for Prevention of Cancer: The D2d Cancer Outcomes (D2dCA) Ancillary Study.

Publication ,  Journal Article
Chatterjee, R; Fuss, P; Vickery, EM; LeBlanc, ES; Sheehan, PR; Lewis, MR; Dolor, RJ; Johnson, KC; Kashyap, SR; Nelson, J; Pittas, AG ...
Published in: J Clin Endocrinol Metab
August 18, 2021

CONTEXT: Observational studies suggest that low vitamin D status may be a risk factor for cancer. OBJECTIVE: In a population with prediabetes and overweight/obesity that is at higher risk of cancer than the general population, we sought to determine if vitamin D supplementation lowers the risk of cancer and precancers. METHODS: The Vitamin D and type 2 diabetes (D2d) cancer outcomes study (D2dCA) is an ancillary study to the D2d study, which was conducted at 22 academic medical centers in the United States. Participants had prediabetes and overweight/obesity and were free of cancer for the previous 5 years. Participants were randomized to receive vitamin D3 4000 IU daily or placebo. At scheduled study visits (4 times/year), cancer and precancer events were identified by questionnaires. Clinical data were collected and adjudicated for all reported events. Cox proportional hazard models compared the hazard ratio (HR) of incident cancers and precancers between groups. RESULTS: Over a median follow-up period of 2.9 years, among 2385 participants (mean age 60 years and 25-hydroxyvitamin D 28 ng/mL), there were 89 cases of cancer. The HR of incident cancer for vitamin D vs placebo was 1.07 (95% CI 0.70, 1.62). Of 241 participants with incident precancers, 239 had colorectal adenomatous polyps. The HR for colorectal polyps for vitamin D vs placebo was 0.83 (95% CI 0.64, 1.07). CONCLUSION: In the D2d population of participants with prediabetes and overweight/obesity, not selected for vitamin D insufficiency, vitamin D supplementation did not have a significant effect on risk of incident cancer or colorectal polyps.

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Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

August 18, 2021

Volume

106

Issue

9

Start / End Page

2767 / 2778

Location

United States

Related Subject Headings

  • Vitamin D
  • Proportional Hazards Models
  • Prediabetic State
  • Precancerous Conditions
  • Overweight
  • Obesity
  • Neoplasms
  • Middle Aged
  • Male
  • Humans
 

Citation

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Chicago
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Chatterjee, R., Fuss, P., Vickery, E. M., LeBlanc, E. S., Sheehan, P. R., Lewis, M. R., … D2d Research Group, . (2021). Vitamin D Supplementation for Prevention of Cancer: The D2d Cancer Outcomes (D2dCA) Ancillary Study. J Clin Endocrinol Metab, 106(9), 2767–2778. https://doi.org/10.1210/clinem/dgab153
Chatterjee, Ranee, Paul Fuss, Ellen M. Vickery, Erin S. LeBlanc, Patricia R. Sheehan, Michael R. Lewis, Rowena J. Dolor, et al. “Vitamin D Supplementation for Prevention of Cancer: The D2d Cancer Outcomes (D2dCA) Ancillary Study.J Clin Endocrinol Metab 106, no. 9 (August 18, 2021): 2767–78. https://doi.org/10.1210/clinem/dgab153.
Chatterjee R, Fuss P, Vickery EM, LeBlanc ES, Sheehan PR, Lewis MR, et al. Vitamin D Supplementation for Prevention of Cancer: The D2d Cancer Outcomes (D2dCA) Ancillary Study. J Clin Endocrinol Metab. 2021 Aug 18;106(9):2767–78.
Chatterjee, Ranee, et al. “Vitamin D Supplementation for Prevention of Cancer: The D2d Cancer Outcomes (D2dCA) Ancillary Study.J Clin Endocrinol Metab, vol. 106, no. 9, Aug. 2021, pp. 2767–78. Pubmed, doi:10.1210/clinem/dgab153.
Chatterjee R, Fuss P, Vickery EM, LeBlanc ES, Sheehan PR, Lewis MR, Dolor RJ, Johnson KC, Kashyap SR, Nelson J, Pittas AG, D2d Research Group. Vitamin D Supplementation for Prevention of Cancer: The D2d Cancer Outcomes (D2dCA) Ancillary Study. J Clin Endocrinol Metab. 2021 Aug 18;106(9):2767–2778.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

August 18, 2021

Volume

106

Issue

9

Start / End Page

2767 / 2778

Location

United States

Related Subject Headings

  • Vitamin D
  • Proportional Hazards Models
  • Prediabetic State
  • Precancerous Conditions
  • Overweight
  • Obesity
  • Neoplasms
  • Middle Aged
  • Male
  • Humans