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Vulvar Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma.

Publication ,  Journal Article
Morse, DC; Park, KE; Chitsazzadeh, V; Li, S; Young, K; Gunther, JR; Dabaja, BS; Duvic, M
Published in: Int J Gynecol Pathol
May 1, 2021

Cutaneous T-cell lymphomas may present with a clinical course that is incongruent with the associated histologic findings. Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma classically presents as an abrupt eruption of disseminated ulcerated annular plaques with aggressive behavior and a poor prognosis. Herein we describe a vulvar primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma with a locally aggressive clinical course that was strikingly responsive to radiation therapy. As aggressive therapy involving systemic chemotherapy is indicated for primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma, appropriate clinico-pathologic correlation is crucial for preventing potentially excessive or insufficient therapeutic intervention. Our case also highlights the pivotal role of both radiation therapy and infection control in the management of aggressive cutaneous vulvar lymphomas.

Duke Scholars

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Published In

Int J Gynecol Pathol

DOI

EISSN

1538-7151

Publication Date

May 1, 2021

Volume

40

Issue

3

Start / End Page

229 / 233

Location

United States

Related Subject Headings

  • Vulvar Neoplasms
  • Treatment Outcome
  • Skin Neoplasms
  • Pathology
  • Middle Aged
  • Lymphoma, T-Cell, Cutaneous
  • Humans
  • Female
  • CD8-Positive T-Lymphocytes
  • 3215 Reproductive medicine
 

Citation

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MLA
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Morse, D. C., Park, K. E., Chitsazzadeh, V., Li, S., Young, K., Gunther, J. R., … Duvic, M. (2021). Vulvar Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma. Int J Gynecol Pathol, 40(3), 229–233. https://doi.org/10.1097/PGP.0000000000000648
Morse, Daniel C., Katherine E. Park, Vida Chitsazzadeh, Shaoying Li, Ken Young, Jillian R. Gunther, Bouthaina S. Dabaja, and Madeleine Duvic. “Vulvar Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma.Int J Gynecol Pathol 40, no. 3 (May 1, 2021): 229–33. https://doi.org/10.1097/PGP.0000000000000648.
Morse DC, Park KE, Chitsazzadeh V, Li S, Young K, Gunther JR, et al. Vulvar Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma. Int J Gynecol Pathol. 2021 May 1;40(3):229–33.
Morse, Daniel C., et al. “Vulvar Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma.Int J Gynecol Pathol, vol. 40, no. 3, May 2021, pp. 229–33. Pubmed, doi:10.1097/PGP.0000000000000648.
Morse DC, Park KE, Chitsazzadeh V, Li S, Young K, Gunther JR, Dabaja BS, Duvic M. Vulvar Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma. Int J Gynecol Pathol. 2021 May 1;40(3):229–233.

Published In

Int J Gynecol Pathol

DOI

EISSN

1538-7151

Publication Date

May 1, 2021

Volume

40

Issue

3

Start / End Page

229 / 233

Location

United States

Related Subject Headings

  • Vulvar Neoplasms
  • Treatment Outcome
  • Skin Neoplasms
  • Pathology
  • Middle Aged
  • Lymphoma, T-Cell, Cutaneous
  • Humans
  • Female
  • CD8-Positive T-Lymphocytes
  • 3215 Reproductive medicine