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Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study.

Publication ,  Journal Article
Oshunbade, AA; Kassahun-Yimer, W; Valle, KA; Hamid, A; Kipchumba, RK; Kamimura, D; Clark, D; White, WB; DeFilippis, AP; Blaha, MJ; Benjamin, EJ ...
Published in: J Am Heart Assoc
April 6, 2021

Background Although Black adults are more likely to die from coronary heart disease (CHD) compared with White adults, few studies have examined the relationship between cigarette smoking and CHD risk among Black adults. We evaluated the relationship between cigarette smoking, incident CHD, and coronary artery calcification in the JHS (Jackson Heart Study). Methods and Results We classified JHS participants without a history of CHD (n=4432) by self-reported baseline smoking status into current, former (smoked at least 400 cigarettes/life) or never smokers at baseline (2000-2004). We further classified current smokers by smoking intensity (number of cigarettes smoked per day [1-19 or ≥20]) and followed for incident CHD (through 2016). Hazard ratios (HR) for incident CHD for each smoking group compared with never smokers were estimated with adjusted Cox proportional hazard regression models. At baseline, there were 548 (12.4%) current, 782 (17.6%) former, and 3102 (70%) never smokers. During follow-up (median, 13.8 years), 254 participants developed CHD. After risk factor adjustment, CHD risk was significantly higher in current smokers compared with never smokers (HR, 2.11; 95% CI, 1.39-3.18); the difference between former smokers and never smokers (HR, 1.37; 95% CI, 1.0-1.90) did not achieve statistical significance. Among current smokers, we did not observe a dose-response effect for CHD risk. Additionally, in multivariable logistic regression models with a subset of our analytic cohort, current smokers had greater odds of coronary artery calcification score >0 compared with never smokers (odds ratio, 2.63; 95% CI, 1.88-3.68). Conclusions In a large prospective cohort of Black adults, current smoking was associated with a >2-fold increased risk of CHD over a median follow-up of greater than a decade.

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Published In

J Am Heart Assoc

DOI

EISSN

2047-9980

Publication Date

April 6, 2021

Volume

10

Issue

7

Start / End Page

e017320

Location

England

Related Subject Headings

  • Vascular Calcification
  • United States
  • Smokers
  • Risk Assessment
  • Non-Smokers
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • Heart Disease Risk Factors
 

Citation

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Oshunbade, A. A., Kassahun-Yimer, W., Valle, K. A., Hamid, A., Kipchumba, R. K., Kamimura, D., … Hall, M. E. (2021). Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study. J Am Heart Assoc, 10(7), e017320. https://doi.org/10.1161/JAHA.120.017320
Oshunbade, Adebamike A., Wondwosen Kassahun-Yimer, Karen A. Valle, Arsalan Hamid, Rodney K. Kipchumba, Daisuke Kamimura, Donald Clark, et al. “Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study.J Am Heart Assoc 10, no. 7 (April 6, 2021): e017320. https://doi.org/10.1161/JAHA.120.017320.
Oshunbade AA, Kassahun-Yimer W, Valle KA, Hamid A, Kipchumba RK, Kamimura D, et al. Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study. J Am Heart Assoc. 2021 Apr 6;10(7):e017320.
Oshunbade, Adebamike A., et al. “Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study.J Am Heart Assoc, vol. 10, no. 7, Apr. 2021, p. e017320. Pubmed, doi:10.1161/JAHA.120.017320.
Oshunbade AA, Kassahun-Yimer W, Valle KA, Hamid A, Kipchumba RK, Kamimura D, Clark D, White WB, DeFilippis AP, Blaha MJ, Benjamin EJ, O’Brien EC, Mentz RJ, Rodriguez CJ, Fox ER, Butler J, Keith RJ, Bhatnagar A, Marie Robertson R, Correa A, Hall ME. Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study. J Am Heart Assoc. 2021 Apr 6;10(7):e017320.
Journal cover image

Published In

J Am Heart Assoc

DOI

EISSN

2047-9980

Publication Date

April 6, 2021

Volume

10

Issue

7

Start / End Page

e017320

Location

England

Related Subject Headings

  • Vascular Calcification
  • United States
  • Smokers
  • Risk Assessment
  • Non-Smokers
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • Heart Disease Risk Factors