Skip to main content
Journal cover image

Determination of hepatitis B phenotype using biochemical and serological markers.

Publication ,  Journal Article
Di Bisceglie, AM; Lombardero, M; Teckman, J; Roberts, L; Janssen, HLA; Belle, SH; Hoofnagle, JH; Hepatitis B Research Network (HBRN),
Published in: J Viral Hepat
April 2017

The aim of this study was to assess the validity of categorization of chronic hepatitis B viral infection into stages or phases based upon measures of disease activity and viral load, assuming these phenotypes will be useful for prognostication and determining the need for antiviral therapy. We assessed the phenotype of hepatitis B of 1,390 adult participants enrolled in the Hepatitis B Research Network Cohort Study, using a computer algorithm. Only 4% were immune tolerant, while 35% had chronic hepatitis B (18% e antigen positive and 17% e antigen negative) while 23% were inactive carriers. Strikingly, 38% of participants did not fit clearly into any one of these groups and were considered indeterminant. The largest subset of indeterminants had elevated serum aminotransferases with low levels of HBV DNA (less than 10,000 iu/mL). Subsequent determination of hepatitis B phenotype on the next available laboratory tests showed that 64% remained indeterminant. These findings call into question the validity of conventional staging of hepatitis B, in large part because of the substantial proportion of patients who do not fit readily into one of the usual stages or phases. Further studies are needed of the indeterminant category of chronic hepatitis B viral infection, including assessments of whether patients in this group are perhaps in transition to another phase or if they are a distinct phenotype with a need to assess liver disease severity and need for antiviral therapy. (ClinicalTrials.gov identifier NCT01263587).

Duke Scholars

Published In

J Viral Hepat

DOI

EISSN

1365-2893

Publication Date

April 2017

Volume

24

Issue

4

Start / End Page

320 / 329

Location

England

Related Subject Headings

  • Young Adult
  • Viral Load
  • Transaminases
  • Phenotype
  • Middle Aged
  • Male
  • Humans
  • Hepatitis B, Chronic
  • Gastroenterology & Hepatology
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Di Bisceglie, A. M., Lombardero, M., Teckman, J., Roberts, L., Janssen, H. L. A., Belle, S. H., … Hepatitis B Research Network (HBRN), . (2017). Determination of hepatitis B phenotype using biochemical and serological markers. J Viral Hepat, 24(4), 320–329. https://doi.org/10.1111/jvh.12643
Di Bisceglie, A. M., M. Lombardero, J. Teckman, L. Roberts, H. L. A. Janssen, S. H. Belle, J. H. Hoofnagle, and J. H. Hepatitis B Research Network (HBRN). “Determination of hepatitis B phenotype using biochemical and serological markers.J Viral Hepat 24, no. 4 (April 2017): 320–29. https://doi.org/10.1111/jvh.12643.
Di Bisceglie AM, Lombardero M, Teckman J, Roberts L, Janssen HLA, Belle SH, et al. Determination of hepatitis B phenotype using biochemical and serological markers. J Viral Hepat. 2017 Apr;24(4):320–9.
Di Bisceglie, A. M., et al. “Determination of hepatitis B phenotype using biochemical and serological markers.J Viral Hepat, vol. 24, no. 4, Apr. 2017, pp. 320–29. Pubmed, doi:10.1111/jvh.12643.
Di Bisceglie AM, Lombardero M, Teckman J, Roberts L, Janssen HLA, Belle SH, Hoofnagle JH, Hepatitis B Research Network (HBRN). Determination of hepatitis B phenotype using biochemical and serological markers. J Viral Hepat. 2017 Apr;24(4):320–329.
Journal cover image

Published In

J Viral Hepat

DOI

EISSN

1365-2893

Publication Date

April 2017

Volume

24

Issue

4

Start / End Page

320 / 329

Location

England

Related Subject Headings

  • Young Adult
  • Viral Load
  • Transaminases
  • Phenotype
  • Middle Aged
  • Male
  • Humans
  • Hepatitis B, Chronic
  • Gastroenterology & Hepatology
  • Female