Skip to main content
Journal cover image

Posttraumatic stress disorder symptoms in patients with acute myeloid leukemia.

Publication ,  Journal Article
Amonoo, HL; LeBlanc, TW; Kavanaugh, AR; Webb, JA; Traeger, LN; Jagielo, AD; Vaughn, DM; Elyze, M; Longley, RM; Fathi, AT; Hobbs, GS; Luger, SM ...
Published in: Cancer
July 15, 2021

BACKGROUND: Patients with acute myeloid leukemia (AML) receiving intensive chemotherapy face a life-threatening illness, isolating hospitalization, and substantial physical and psychological symptoms. However, data are limited regarding risk factors of posttraumatic stress disorder (PTSD) symptoms in this population. METHODS: The authors conducted a secondary analysis of data from 160 patients with high-risk AML who were enrolled in a supportive care trial. The PTSD Checklist-Civilian Version was used to assess PTSD symptoms at 1 month after AML diagnosis. The Brief COPE and the Functional Assessment of Cancer Therapy-Leukemia were to assess coping and quality of life (QOL), respectively. In addition, multivariate regression models were constructed to assess the relation between PTSD symptoms and baseline sociodemographic factors, coping, and QOL. RESULTS: Twenty-eight percent of patients reported PTSD symptoms, describing high rates of intrusion, avoidance, and hypervigiliance. Baseline sociodemographic factors significantly associated with PTSD symptoms were age (B = -0.26; P = .002), race (B = -8.78; P = .004), and postgraduate education (B = -6.30; P = .029). Higher baseline QOL (B = -0.37; P ≤ .001) and less decline in QOL during hospitalization (B = -0.05; P = .224) were associated with fewer PTSD symptoms. Approach-oriented coping (B = -0.92; P = .001) was associated with fewer PTSD symptoms, whereas avoidant coping (B = 2.42; P ≤ .001) was associated with higher PTSD symptoms. CONCLUSIONS: A substantial proportion of patients with AML report clinically significant PTSD symptoms 1 month after initiating intensive chemotherapy. Patients' baseline QOL, coping strategies, and extent of QOL decline during hospitalization emerge as important risk factors for PTSD, underscoring the need for supportive oncology interventions to reduce the risk of PTSD in this population.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

July 15, 2021

Volume

127

Issue

14

Start / End Page

2500 / 2506

Location

United States

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Quality of Life
  • Oncology & Carcinogenesis
  • Leukemia, Myeloid, Acute
  • Humans
  • Hospitalization
  • Adaptation, Psychological
  • 4206 Public health
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Amonoo, H. L., LeBlanc, T. W., Kavanaugh, A. R., Webb, J. A., Traeger, L. N., Jagielo, A. D., … El-Jawahri, A. (2021). Posttraumatic stress disorder symptoms in patients with acute myeloid leukemia. Cancer, 127(14), 2500–2506. https://doi.org/10.1002/cncr.33524
Amonoo, Hermioni L., Thomas W. LeBlanc, Alison R. Kavanaugh, Jason A. Webb, Lara N. Traeger, Annemarie D. Jagielo, Dagny M. Vaughn, et al. “Posttraumatic stress disorder symptoms in patients with acute myeloid leukemia.Cancer 127, no. 14 (July 15, 2021): 2500–2506. https://doi.org/10.1002/cncr.33524.
Amonoo HL, LeBlanc TW, Kavanaugh AR, Webb JA, Traeger LN, Jagielo AD, et al. Posttraumatic stress disorder symptoms in patients with acute myeloid leukemia. Cancer. 2021 Jul 15;127(14):2500–6.
Amonoo, Hermioni L., et al. “Posttraumatic stress disorder symptoms in patients with acute myeloid leukemia.Cancer, vol. 127, no. 14, July 2021, pp. 2500–06. Pubmed, doi:10.1002/cncr.33524.
Amonoo HL, LeBlanc TW, Kavanaugh AR, Webb JA, Traeger LN, Jagielo AD, Vaughn DM, Elyze M, Longley RM, Fathi AT, Hobbs GS, Brunner AM, O’Connor NR, Luger SM, Gustin JL, Bhatnagar B, Horick NK, El-Jawahri A. Posttraumatic stress disorder symptoms in patients with acute myeloid leukemia. Cancer. 2021 Jul 15;127(14):2500–2506.
Journal cover image

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

July 15, 2021

Volume

127

Issue

14

Start / End Page

2500 / 2506

Location

United States

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Quality of Life
  • Oncology & Carcinogenesis
  • Leukemia, Myeloid, Acute
  • Humans
  • Hospitalization
  • Adaptation, Psychological
  • 4206 Public health
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services