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Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology.

Publication ,  Journal Article
Rabjohns, EM; Hurst, K; Ghosh, A; Cuellar, MC; Rampersad, RR; Tarrant, TK
Published in: Curr Allergy Asthma Rep
March 25, 2021

PURPOSE OF REVIEW: The purpose of this review is to recognize clinical features of Paget's disease of bone and to describe how the osteoclast, a myeloid-derived cell responsible for bone resorption, contributes to the disease. RECENT FINDINGS: Recent studies have identified several variants in SQSTM1, OPTN, and other genes that may predispose individuals to Paget's disease of bone; studies of these genes and their protein products have elucidated new roles for these proteins in bone physiology. Understanding the pathologic mechanisms in the Pagetic osteoclast may lead to the identification of future treatment targets for other inflammatory and autoimmune diseases characterized by abnormal bone erosion and/or osteoclast activation.

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Published In

Curr Allergy Asthma Rep

DOI

EISSN

1534-6315

Publication Date

March 25, 2021

Volume

21

Issue

4

Start / End Page

23

Location

United States

Related Subject Headings

  • Osteoclasts
  • Osteitis Deformans
  • Humans
  • Bone and Bones
  • Bone Remodeling
  • Allergy
  • Algorithms
  • 3204 Immunology
  • 3201 Cardiovascular medicine and haematology
 

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Rabjohns, E. M., Hurst, K., Ghosh, A., Cuellar, M. C., Rampersad, R. R., & Tarrant, T. K. (2021). Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology. Curr Allergy Asthma Rep, 21(4), 23. https://doi.org/10.1007/s11882-021-01001-2
Rabjohns, Emily M., Katlyn Hurst, Arin Ghosh, Maria C. Cuellar, Rishi R. Rampersad, and Teresa K. Tarrant. “Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology.Curr Allergy Asthma Rep 21, no. 4 (March 25, 2021): 23. https://doi.org/10.1007/s11882-021-01001-2.
Rabjohns EM, Hurst K, Ghosh A, Cuellar MC, Rampersad RR, Tarrant TK. Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology. Curr Allergy Asthma Rep. 2021 Mar 25;21(4):23.
Rabjohns, Emily M., et al. “Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology.Curr Allergy Asthma Rep, vol. 21, no. 4, Mar. 2021, p. 23. Pubmed, doi:10.1007/s11882-021-01001-2.
Rabjohns EM, Hurst K, Ghosh A, Cuellar MC, Rampersad RR, Tarrant TK. Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology. Curr Allergy Asthma Rep. 2021 Mar 25;21(4):23.
Journal cover image

Published In

Curr Allergy Asthma Rep

DOI

EISSN

1534-6315

Publication Date

March 25, 2021

Volume

21

Issue

4

Start / End Page

23

Location

United States

Related Subject Headings

  • Osteoclasts
  • Osteitis Deformans
  • Humans
  • Bone and Bones
  • Bone Remodeling
  • Allergy
  • Algorithms
  • 3204 Immunology
  • 3201 Cardiovascular medicine and haematology