The frontier of live tissue imaging across space and time.
Publication
, Journal Article
Huang, Q; Garrett, A; Bose, S; Blocker, S; Rios, AC; Clevers, H; Shen, X
Published in: Cell Stem Cell
April 1, 2021
What you see is what you get-imaging techniques have long been essential for visualization and understanding of tissue development, homeostasis, and regeneration, which are driven by stem cell self-renewal and differentiation. Advances in molecular and tissue modeling techniques in the last decade are providing new imaging modalities to explore tissue heterogeneity and plasticity. Here we describe current state-of-the-art imaging modalities for tissue research at multiple scales, with a focus on explaining key tradeoffs such as spatial resolution, penetration depth, capture time/frequency, and moieties. We explore emerging tissue modeling and molecular tools that improve resolution, specificity, and throughput.
Duke Scholars
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Published In
Cell Stem Cell
DOI
EISSN
1875-9777
Publication Date
April 1, 2021
Volume
28
Issue
4
Start / End Page
603 / 622
Location
United States
Related Subject Headings
- Developmental Biology
- Cell Differentiation
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences
- 06 Biological Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Huang, Q., Garrett, A., Bose, S., Blocker, S., Rios, A. C., Clevers, H., & Shen, X. (2021). The frontier of live tissue imaging across space and time. Cell Stem Cell, 28(4), 603–622. https://doi.org/10.1016/j.stem.2021.02.010
Huang, Qiang, Aliesha Garrett, Shree Bose, Stephanie Blocker, Anne C. Rios, Hans Clevers, and Xiling Shen. “The frontier of live tissue imaging across space and time.” Cell Stem Cell 28, no. 4 (April 1, 2021): 603–22. https://doi.org/10.1016/j.stem.2021.02.010.
Huang Q, Garrett A, Bose S, Blocker S, Rios AC, Clevers H, et al. The frontier of live tissue imaging across space and time. Cell Stem Cell. 2021 Apr 1;28(4):603–22.
Huang, Qiang, et al. “The frontier of live tissue imaging across space and time.” Cell Stem Cell, vol. 28, no. 4, Apr. 2021, pp. 603–22. Pubmed, doi:10.1016/j.stem.2021.02.010.
Huang Q, Garrett A, Bose S, Blocker S, Rios AC, Clevers H, Shen X. The frontier of live tissue imaging across space and time. Cell Stem Cell. 2021 Apr 1;28(4):603–622.
Published In
Cell Stem Cell
DOI
EISSN
1875-9777
Publication Date
April 1, 2021
Volume
28
Issue
4
Start / End Page
603 / 622
Location
United States
Related Subject Headings
- Developmental Biology
- Cell Differentiation
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences
- 06 Biological Sciences