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Discovering the landscape of protein modifications.

Publication ,  Journal Article
Keenan, EK; Zachman, DK; Hirschey, MD
Published in: Mol Cell
May 6, 2021

Protein modifications modulate nearly every aspect of cell biology in organisms, ranging from Archaea to Eukaryotes. The earliest evidence of covalent protein modifications was found in the early 20th century by studying the amino acid composition of proteins by chemical hydrolysis. These discoveries challenged what defined a canonical amino acid. The advent and rapid adoption of mass-spectrometry-based proteomics in the latter part of the 20th century enabled a veritable explosion in the number of known protein modifications, with more than 500 discrete modifications counted today. Now, new computational tools in data science, machine learning, and artificial intelligence are poised to allow researchers to make significant progress in discovering new protein modifications and determining their function. In this review, we take an opportunity to revisit the historical discovery of key post-translational modifications, quantify the current landscape of covalent protein adducts, and assess the role that new computational tools will play in the future of this field.

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Published In

Mol Cell

DOI

EISSN

1097-4164

Publication Date

May 6, 2021

Volume

81

Issue

9

Start / End Page

1868 / 1878

Location

United States

Related Subject Headings

  • Structure-Activity Relationship
  • Proteomics
  • Proteins
  • Protein Processing, Post-Translational
  • Protein Conformation
  • Humans
  • Developmental Biology
  • Databases, Protein
  • Computational Biology
  • Artificial Intelligence
 

Citation

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Keenan, E. K., Zachman, D. K., & Hirschey, M. D. (2021). Discovering the landscape of protein modifications. Mol Cell, 81(9), 1868–1878. https://doi.org/10.1016/j.molcel.2021.03.015
Keenan, E Keith, Derek K. Zachman, and Matthew D. Hirschey. “Discovering the landscape of protein modifications.Mol Cell 81, no. 9 (May 6, 2021): 1868–78. https://doi.org/10.1016/j.molcel.2021.03.015.
Keenan EK, Zachman DK, Hirschey MD. Discovering the landscape of protein modifications. Mol Cell. 2021 May 6;81(9):1868–78.
Keenan, E. Keith, et al. “Discovering the landscape of protein modifications.Mol Cell, vol. 81, no. 9, May 2021, pp. 1868–78. Pubmed, doi:10.1016/j.molcel.2021.03.015.
Keenan EK, Zachman DK, Hirschey MD. Discovering the landscape of protein modifications. Mol Cell. 2021 May 6;81(9):1868–1878.
Journal cover image

Published In

Mol Cell

DOI

EISSN

1097-4164

Publication Date

May 6, 2021

Volume

81

Issue

9

Start / End Page

1868 / 1878

Location

United States

Related Subject Headings

  • Structure-Activity Relationship
  • Proteomics
  • Proteins
  • Protein Processing, Post-Translational
  • Protein Conformation
  • Humans
  • Developmental Biology
  • Databases, Protein
  • Computational Biology
  • Artificial Intelligence