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National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report.

Publication ,  Journal Article
Kitko, CL; Pidala, J; Schoemans, HM; Lawitschka, A; Flowers, ME; Cowen, EW; Tkaczyk, E; Farhadfar, N; Jain, S; Steven, P; Luo, ZK; Ogawa, Y ...
Published in: Transplant Cell Ther
July 2021

Recognition of the earliest signs and symptoms of chronic graft-versus-host disease (GVHD) that lead to severe manifestations remains a challenge. The standardization provided by the National Institutes of Health (NIH) 2005 and 2014 consensus projects has helped improve diagnostic accuracy and severity scoring for clinical trials, but utilization of these tools in routine clinical practice is variable. Additionally, when patients meet the NIH diagnostic criteria, many already have significant morbidity and possibly irreversible organ damage. The goals of this early diagnosis project are 2-fold. First, we provide consensus recommendations regarding implementation of the current NIH diagnostic guidelines into routine transplant care, outside of clinical trials, aiming to enhance early clinical recognition of chronic GVHD. Second, we propose directions for future research efforts to enable discovery of new, early laboratory as well as clinical indicators of chronic GVHD, both globally and for highly morbid organ-specific manifestations. Identification of early features of chronic GVHD that have high positive predictive value for progression to more severe manifestations of the disease could potentially allow for future pre-emptive clinical trials.

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Published In

Transplant Cell Ther

DOI

EISSN

2666-6367

Publication Date

July 2021

Volume

27

Issue

7

Start / End Page

545 / 557

Location

United States

Related Subject Headings

  • United States
  • National Institutes of Health (U.S.)
  • Immunology
  • Humans
  • Graft vs Host Disease
  • Early Diagnosis
  • Consensus
  • Chronic Disease
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
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Kitko, C. L., Pidala, J., Schoemans, H. M., Lawitschka, A., Flowers, M. E., Cowen, E. W., … Cutler, C. (2021). National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report. Transplant Cell Ther, 27(7), 545–557. https://doi.org/10.1016/j.jtct.2021.03.033
Kitko, Carrie L., Joseph Pidala, Hélène M. Schoemans, Anita Lawitschka, Mary E. Flowers, Edward W. Cowen, Eric Tkaczyk, et al. “National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report.Transplant Cell Ther 27, no. 7 (July 2021): 545–57. https://doi.org/10.1016/j.jtct.2021.03.033.
Kitko CL, Pidala J, Schoemans HM, Lawitschka A, Flowers ME, Cowen EW, Tkaczyk E, Farhadfar N, Jain S, Steven P, Luo ZK, Ogawa Y, Stern M, Yanik GA, Cuvelier GDE, Cheng G-S, Holtan SG, Schultz KR, Martin PJ, Lee SJ, Pavletic SZ, Wolff D, Paczesny S, Blazar BR, Sarantopoulos S, Socie G, Greinix H, Cutler C. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report. Transplant Cell Ther. 2021 Jul;27(7):545–557.

Published In

Transplant Cell Ther

DOI

EISSN

2666-6367

Publication Date

July 2021

Volume

27

Issue

7

Start / End Page

545 / 557

Location

United States

Related Subject Headings

  • United States
  • National Institutes of Health (U.S.)
  • Immunology
  • Humans
  • Graft vs Host Disease
  • Early Diagnosis
  • Consensus
  • Chronic Disease
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences