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Therapies for hepatocellular carcinoma: overview, clinical indications, and comparative outcome evaluation-part one: curative intention.

Publication ,  Journal Article
Yacoub, JH; Hsu, CC; Fishbein, TM; Mauro, D; Moon, A; He, AR; Bashir, MR; Burke, LMB
Published in: Abdom Radiol (NY)
August 2021

Hepatocellular carcinoma (HCC) offers unique management challenges as it commonly occurs in the setting of underlying chronic liver disease. The management of HCC is directed primarily by the clinical stage. The most commonly used staging system is the Barcelona-Clinic Liver Cancer system, which considers tumor burden based on imaging, liver function and the patient's performance status. Early-stage HCC can be managed with therapies of curative intent including surgical resection, liver transplantation, and ablative therapies. This manuscript reviews the various treatment options for HCC with a curative intent, such as locablative therapy types, surgical resection, and transplant. Indications, contraindications and outcomes of the various treatment options are reviewed. Multiple concepts relating to liver transplant are discussed including Milan criteria, OPTN policy, MELD exception points, downstaging to transplant and bridging to transplant.

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Published In

Abdom Radiol (NY)

DOI

EISSN

2366-0058

Publication Date

August 2021

Volume

46

Issue

8

Start / End Page

3528 / 3539

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Neoplasm Staging
  • Liver Transplantation
  • Liver Neoplasms
  • Intention
  • Humans
  • Carcinoma, Hepatocellular
 

Citation

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Yacoub, J. H., Hsu, C. C., Fishbein, T. M., Mauro, D., Moon, A., He, A. R., … Burke, L. M. B. (2021). Therapies for hepatocellular carcinoma: overview, clinical indications, and comparative outcome evaluation-part one: curative intention. Abdom Radiol (NY), 46(8), 3528–3539. https://doi.org/10.1007/s00261-021-03069-w
Yacoub, Joseph H., Christine C. Hsu, Thomas M. Fishbein, David Mauro, Andrew Moon, Aiwu R. He, Mustafa R. Bashir, and Lauren M. B. Burke. “Therapies for hepatocellular carcinoma: overview, clinical indications, and comparative outcome evaluation-part one: curative intention.Abdom Radiol (NY) 46, no. 8 (August 2021): 3528–39. https://doi.org/10.1007/s00261-021-03069-w.
Yacoub JH, Hsu CC, Fishbein TM, Mauro D, Moon A, He AR, et al. Therapies for hepatocellular carcinoma: overview, clinical indications, and comparative outcome evaluation-part one: curative intention. Abdom Radiol (NY). 2021 Aug;46(8):3528–39.
Yacoub, Joseph H., et al. “Therapies for hepatocellular carcinoma: overview, clinical indications, and comparative outcome evaluation-part one: curative intention.Abdom Radiol (NY), vol. 46, no. 8, Aug. 2021, pp. 3528–39. Pubmed, doi:10.1007/s00261-021-03069-w.
Yacoub JH, Hsu CC, Fishbein TM, Mauro D, Moon A, He AR, Bashir MR, Burke LMB. Therapies for hepatocellular carcinoma: overview, clinical indications, and comparative outcome evaluation-part one: curative intention. Abdom Radiol (NY). 2021 Aug;46(8):3528–3539.
Journal cover image

Published In

Abdom Radiol (NY)

DOI

EISSN

2366-0058

Publication Date

August 2021

Volume

46

Issue

8

Start / End Page

3528 / 3539

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Neoplasm Staging
  • Liver Transplantation
  • Liver Neoplasms
  • Intention
  • Humans
  • Carcinoma, Hepatocellular