The Placenta as a Barrier to Viral Infections.
Publication
, Journal Article
Delorme-Axford, E; Sadovsky, Y; Coyne, CB
Published in: Annu Rev Virol
November 2014
Throughout pregnancy, the placenta acts as a physical and immunological barrier against the hematogenous transmission of viruses from mother to fetus. Despite this, very little is known regarding the specific mechanisms by which the placenta shields the developing fetus from viral infections or about the strategies utilized by select viruses to bypass and/or weaken the placental barrier. In this review, we summarize studies regarding virus-host interactions at the placental interface and explore key areas for future investigation. We focus our review on placental trophoblasts, which form the barrier between maternal and fetal circulations and thus govern the cross talk between the maternal and fetal microenvironments.
Duke Scholars
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Published In
Annu Rev Virol
DOI
ISSN
2327-056X
Publication Date
November 2014
Volume
1
Issue
1
Start / End Page
133 / 146
Location
United States
Related Subject Headings
- 3107 Microbiology
Citation
APA
Chicago
ICMJE
MLA
NLM
Delorme-Axford, E., Sadovsky, Y., & Coyne, C. B. (2014). The Placenta as a Barrier to Viral Infections. Annu Rev Virol, 1(1), 133–146. https://doi.org/10.1146/annurev-virology-031413-085524
Delorme-Axford, Elizabeth, Yoel Sadovsky, and Carolyn B. Coyne. “The Placenta as a Barrier to Viral Infections.” Annu Rev Virol 1, no. 1 (November 2014): 133–46. https://doi.org/10.1146/annurev-virology-031413-085524.
Delorme-Axford E, Sadovsky Y, Coyne CB. The Placenta as a Barrier to Viral Infections. Annu Rev Virol. 2014 Nov;1(1):133–46.
Delorme-Axford, Elizabeth, et al. “The Placenta as a Barrier to Viral Infections.” Annu Rev Virol, vol. 1, no. 1, Nov. 2014, pp. 133–46. Pubmed, doi:10.1146/annurev-virology-031413-085524.
Delorme-Axford E, Sadovsky Y, Coyne CB. The Placenta as a Barrier to Viral Infections. Annu Rev Virol. 2014 Nov;1(1):133–146.
Published In
Annu Rev Virol
DOI
ISSN
2327-056X
Publication Date
November 2014
Volume
1
Issue
1
Start / End Page
133 / 146
Location
United States
Related Subject Headings
- 3107 Microbiology