Skip to main content

Sonorheometry: A new method for assessing coagulation potential

Publication ,  Conference
Viola, F; William Mauldin, F; Tropello, SP; Gail Macik, B; Lawrence, MB; Walker, WF
Published in: Proceedings - IEEE Ultrasonics Symposium
December 1, 2007

Inappropriate blood coagulation is a significant contributing factor in the onset of potentially fatal thrombotic events such as myocardial infarction, stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE). The ability to recognize and quantify thrombotic disorders is thus critical to implement appropriate treatment. We have developed a novel technique, called sonorheometry, which can identify an increased or decreased propensity to clot by observing the coagulation rate and mechanical characteristics of the developing clot. Sonorheometry utilizes acoustic radiation force with ultrasound motion tracking. We have designed and fabricated a sonorheometry system which is controlled by an external laptop computer. In the experiments presented in this paper, we analyzed blood samples of lml using a 10MHz, fixed focus transducer at a PRF of 400Hz. Measurements were performed every 6 sec for 7 min after blood was drawn. Returning echoes were processed using a spline-based tracking method to determine the time dependent deformations induced by the application of the force. These deformations were modeled using two Voigt models in series with added inertia to generate data depicting various mechanical properties. We present time displacement curves that show maximum displacements of 40μm; detectable displacements decrease as the blood clots. We also show the viscoelastic parameters obtained from the model. These results show that sonorheometry could be used to assess coagulation potential. © 2007 IEEE.

Duke Scholars

Published In

Proceedings - IEEE Ultrasonics Symposium

DOI

ISSN

1051-0117

ISBN

9781424413836

Publication Date

December 1, 2007

Start / End Page

1001 / 1004
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Viola, F., William Mauldin, F., Tropello, S. P., Gail Macik, B., Lawrence, M. B., & Walker, W. F. (2007). Sonorheometry: A new method for assessing coagulation potential. In Proceedings - IEEE Ultrasonics Symposium (pp. 1001–1004). https://doi.org/10.1109/ULTSYM.2007.255
Viola, F., F. William Mauldin, S. P. Tropello, B. Gail Macik, M. B. Lawrence, and W. F. Walker. “Sonorheometry: A new method for assessing coagulation potential.” In Proceedings - IEEE Ultrasonics Symposium, 1001–4, 2007. https://doi.org/10.1109/ULTSYM.2007.255.
Viola F, William Mauldin F, Tropello SP, Gail Macik B, Lawrence MB, Walker WF. Sonorheometry: A new method for assessing coagulation potential. In: Proceedings - IEEE Ultrasonics Symposium. 2007. p. 1001–4.
Viola, F., et al. “Sonorheometry: A new method for assessing coagulation potential.” Proceedings - IEEE Ultrasonics Symposium, 2007, pp. 1001–04. Scopus, doi:10.1109/ULTSYM.2007.255.
Viola F, William Mauldin F, Tropello SP, Gail Macik B, Lawrence MB, Walker WF. Sonorheometry: A new method for assessing coagulation potential. Proceedings - IEEE Ultrasonics Symposium. 2007. p. 1001–1004.

Published In

Proceedings - IEEE Ultrasonics Symposium

DOI

ISSN

1051-0117

ISBN

9781424413836

Publication Date

December 1, 2007

Start / End Page

1001 / 1004