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Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells.

Publication ,  Journal Article
Bunis, DG; Bronevetsky, Y; Krow-Lucal, E; Bhakta, NR; Kim, CC; Nerella, S; Jones, N; Mendoza, VF; Bryson, YJ; Gern, JE; Rutishauser, RL ...
Published in: Cell Rep
January 5, 2021

Whereas the human fetal immune system is poised to generate immune tolerance and suppress inflammation in utero, an adult-like immune system emerges to orchestrate anti-pathogen immune responses in post-natal life. It has been posited that cells of the adult immune system arise as a discrete ontological "layer" of hematopoietic stem-progenitor cells (HSPCs) and their progeny; evidence supporting this model in humans has, however, been inconclusive. Here, we combine bulk and single-cell transcriptional profiling of lymphoid cells, myeloid cells, and HSPCs from fetal, perinatal, and adult developmental stages to demonstrate that the fetal-to-adult transition occurs progressively along a continuum of maturity-with a substantial degree of inter-individual variation at the time of birth-rather than via a transition between discrete waves. These findings have important implications for the design of strategies for prophylaxis against infection in the newborn and for the use of umbilical cord blood (UCB) in the setting of transplantation.

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Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

January 5, 2021

Volume

34

Issue

1

Start / End Page

108573

Location

United States

Related Subject Headings

  • Transcriptome
  • T-Lymphocytes
  • Single-Cell Analysis
  • Sequence Analysis, RNA
  • Pregnancy
  • Myeloid Cells
  • Lymphocytes
  • Immunity
  • Humans
  • Hematopoietic Stem Cells
 

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Bunis, D. G., Bronevetsky, Y., Krow-Lucal, E., Bhakta, N. R., Kim, C. C., Nerella, S., … Burt, T. D. (2021). Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells. Cell Rep, 34(1), 108573. https://doi.org/10.1016/j.celrep.2020.108573
Bunis, Daniel G., Yelena Bronevetsky, Elisabeth Krow-Lucal, Nirav R. Bhakta, Charles C. Kim, Srilaxmi Nerella, Norman Jones, et al. “Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells.Cell Rep 34, no. 1 (January 5, 2021): 108573. https://doi.org/10.1016/j.celrep.2020.108573.
Bunis DG, Bronevetsky Y, Krow-Lucal E, Bhakta NR, Kim CC, Nerella S, et al. Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells. Cell Rep. 2021 Jan 5;34(1):108573.
Bunis, Daniel G., et al. “Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells.Cell Rep, vol. 34, no. 1, Jan. 2021, p. 108573. Pubmed, doi:10.1016/j.celrep.2020.108573.
Bunis DG, Bronevetsky Y, Krow-Lucal E, Bhakta NR, Kim CC, Nerella S, Jones N, Mendoza VF, Bryson YJ, Gern JE, Rutishauser RL, Ye CJ, Sirota M, McCune JM, Burt TD. Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells. Cell Rep. 2021 Jan 5;34(1):108573.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

January 5, 2021

Volume

34

Issue

1

Start / End Page

108573

Location

United States

Related Subject Headings

  • Transcriptome
  • T-Lymphocytes
  • Single-Cell Analysis
  • Sequence Analysis, RNA
  • Pregnancy
  • Myeloid Cells
  • Lymphocytes
  • Immunity
  • Humans
  • Hematopoietic Stem Cells