Esophageal disease among childhood cancer survivors-A report from the Childhood Cancer Survivors Study.
There is limited information addressing the occurrence of esophageal strictures among the growing population of survivors of childhood cancer. Using the Childhood Cancer Survivor Study, we analyzed data from 17,121 5-year survivors and 3400 siblings to determine the prevalence and risk factors for esophageal strictures. Prevalence among survivors was 2.0% (95% confidence interval [CI]: 1.8-2.2%), representing a 7.6-fold increased risk compared to siblings. Factors significantly associated with risk of esophageal stricture included diagnosis of Hodgkin lymphoma, greater chest radiation dose, younger age at cancer diagnosis, platinum chemotherapy, and hematopoietic stem cell transplantation. While uncommon, survivors are at risk for therapy-related esophageal strictures.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Survivors
- Risk Factors
- Oncology & Carcinogenesis
- Neoplasms
- Humans
- Hodgkin Disease
- Esophageal Diseases
- Constriction, Pathologic
- Child
- Cancer Survivors
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Survivors
- Risk Factors
- Oncology & Carcinogenesis
- Neoplasms
- Humans
- Hodgkin Disease
- Esophageal Diseases
- Constriction, Pathologic
- Child
- Cancer Survivors