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A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice.

Publication ,  Journal Article
Martinez, DR; Schaefer, A; Gobeil, S; Li, D; De la Cruz, G; Parks, R; Lu, X; Barr, M; Manne, K; Mansouri, K; Edwards, RJ; Yount, B; Anasti, K ...
Published in: bioRxiv
April 28, 2021

SARS-CoV in 2003, SARS-CoV-2 in 2019, and SARS-CoV-2 variants of concern (VOC) can cause deadly infections, underlining the importance of developing broadly effective countermeasures against Group 2B Sarbecoviruses, which could be key in the rapid prevention and mitigation of future zoonotic events. Here, we demonstrate the neutralization of SARS-CoV, bat CoVs WIV-1 and RsSHC014, and SARS-CoV-2 variants D614G, B.1.1.7, B.1.429, B1.351 by a receptor-binding domain (RBD)-specific antibody DH1047. Prophylactic and therapeutic treatment with DH1047 demonstrated protection against SARS-CoV, WIV-1, RsSHC014, and SARS-CoV-2 B1.351infection in mice. Binding and structural analysis showed high affinity binding of DH1047 to an epitope that is highly conserved among Sarbecoviruses. We conclude that DH1047 is a broadly neutralizing and protective antibody that can prevent infection and mitigate outbreaks caused by SARS-like strains and SARS-CoV-2 variants. Our results argue that the RBD conserved epitope bound by DH1047 is a rational target for pan Group 2B coronavirus vaccines.

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bioRxiv

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Publication Date

April 28, 2021

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United States
 

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Martinez, D. R., Schaefer, A., Gobeil, S., Li, D., De la Cruz, G., Parks, R., … Baric, R. S. (2021). A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice. BioRxiv. https://doi.org/10.1101/2021.04.27.441655
Martinez, David R., Alexandra Schaefer, Sophie Gobeil, Dapeng Li, Gabriela De la Cruz, Robert Parks, Xiaozhi Lu, et al. “A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice.BioRxiv, April 28, 2021. https://doi.org/10.1101/2021.04.27.441655.
Martinez DR, Schaefer A, Gobeil S, Li D, De la Cruz G, Parks R, et al. A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice. bioRxiv. 2021 Apr 28;
Martinez, David R., et al. “A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice.BioRxiv, Apr. 2021. Pubmed, doi:10.1101/2021.04.27.441655.
Martinez DR, Schaefer A, Gobeil S, Li D, De la Cruz G, Parks R, Lu X, Barr M, Manne K, Mansouri K, Edwards RJ, Yount B, Anasti K, Montgomery SA, Shen S, Zhou T, Kwong PD, Graham BS, Mascola JR, Montefiori DC, Alam M, Sempowski GD, Wiehe K, Saunders KO, Acharya P, Haynes BF, Baric RS. A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice. bioRxiv. 2021 Apr 28;

Published In

bioRxiv

DOI

Publication Date

April 28, 2021

Location

United States