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Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection.

Publication ,  Journal Article
Byrne, JD; Young, CC; Chu, JN; Pursley, J; Chen, MX; Wentworth, AJ; Feng, A; Kirtane, AR; Remillard, KA; Hancox, CI; Bhagwat, MS; Machado, N ...
Published in: Adv Sci (Weinh)
June 2021

Cancer patients undergoing therapeutic radiation routinely develop injury of the adjacent gastrointestinal (GI) tract mucosa due to treatment. To reduce radiation dose to critical GI structures including the rectum and oral mucosa, 3D-printed GI radioprotective devices composed of high-Z materials are generated from patient CT scans. In a radiation proctitis rat model, a significant reduction in crypt injury is demonstrated with the device compared to without (p < 0.0087). Optimal device placement for radiation attenuation is further confirmed in a swine model. Dosimetric modeling in oral cavity cancer patients demonstrates a 30% radiation dose reduction to the normal buccal mucosa and a 15.2% dose reduction in the rectum for prostate cancer patients with the radioprotectant material in place compared to without. Finally, it is found that the rectal radioprotectant device is more cost-effective compared to a hydrogel rectal spacer. Taken together, these data suggest that personalized radioprotectant devices may be used to reduce GI tissue injury in cancer patients undergoing therapeutic radiation.

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Published In

Adv Sci (Weinh)

DOI

EISSN

2198-3844

Publication Date

June 2021

Volume

8

Issue

12

Start / End Page

2100510

Location

Germany

Related Subject Headings

  • Tomography, X-Ray Computed
  • Swine
  • Rats, Sprague-Dawley
  • Rats
  • Radiation Protection
  • Radiation Injuries
  • Printing, Three-Dimensional
  • Organs at Risk
  • Mucous Membrane
  • Mouth Neoplasms
 

Citation

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Byrne, J. D., Young, C. C., Chu, J. N., Pursley, J., Chen, M. X., Wentworth, A. J., … Traverso, G. (2021). Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection. Adv Sci (Weinh), 8(12), 2100510. https://doi.org/10.1002/advs.202100510
Byrne, James D., Cameron C. Young, Jacqueline N. Chu, Jennifer Pursley, Mu Xian Chen, Adam J. Wentworth, Annie Feng, et al. “Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection.Adv Sci (Weinh) 8, no. 12 (June 2021): 2100510. https://doi.org/10.1002/advs.202100510.
Byrne JD, Young CC, Chu JN, Pursley J, Chen MX, Wentworth AJ, et al. Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection. Adv Sci (Weinh). 2021 Jun;8(12):2100510.
Byrne, James D., et al. “Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection.Adv Sci (Weinh), vol. 8, no. 12, June 2021, p. 2100510. Pubmed, doi:10.1002/advs.202100510.
Byrne JD, Young CC, Chu JN, Pursley J, Chen MX, Wentworth AJ, Feng A, Kirtane AR, Remillard KA, Hancox CI, Bhagwat MS, Machado N, Hua T, Tamang SM, Collins JE, Ishida K, Hayward A, Becker SL, Edgington SK, Schoenfeld JD, Jeck WR, Hur C, Traverso G. Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection. Adv Sci (Weinh). 2021 Jun;8(12):2100510.
Journal cover image

Published In

Adv Sci (Weinh)

DOI

EISSN

2198-3844

Publication Date

June 2021

Volume

8

Issue

12

Start / End Page

2100510

Location

Germany

Related Subject Headings

  • Tomography, X-Ray Computed
  • Swine
  • Rats, Sprague-Dawley
  • Rats
  • Radiation Protection
  • Radiation Injuries
  • Printing, Three-Dimensional
  • Organs at Risk
  • Mucous Membrane
  • Mouth Neoplasms