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Lipid diversity in clostridia.

Publication ,  Journal Article
Guan, Z; Goldfine, H
Published in: Biochim Biophys Acta Mol Cell Biol Lipids
September 2021

Studies of the lipidomes of twenty-one species of clostridia have revealed considerable diversity. Even among those species now defined as Clostridium sensu stricto, which are related to Clostridium butyricum, the type species, lipid analysis has shown that a number of distinct clades have characteristic polar lipids. All species of Clostridium sensu stricto have phosphatidylethanolamine, phosphatidylglycerol and cardiolipin which are present as all acyl or alk-1'-enyl acyl (plasmalogen) species. In addition, almost every clade has specialized polar lipids. For example, the group closely related to Clostridium beijerinckii and several other solventogenic species has glycerol acetals of plasmenylethanolamine, which protects the membrane bilayer arrangement when the lipids are highly unsaturated or in the presence of solvents. The group related to Clostridium novyi has aminoacyl-phosphatidylglycerol, which protects these pathogens from cationic antimicrobial peptides (CAMPs) of innate immunity. Clostridium botulinum species, which fall into several groups, align with these clades, and have the same specific lipids. This review will present the current state of knowledge on clostridial lipids.

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Published In

Biochim Biophys Acta Mol Cell Biol Lipids

DOI

EISSN

1879-2618

Publication Date

September 2021

Volume

1866

Issue

9

Start / End Page

158966

Location

Netherlands

Related Subject Headings

  • Lipidomics
  • Clostridium
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

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Guan, Z., & Goldfine, H. (2021). Lipid diversity in clostridia. Biochim Biophys Acta Mol Cell Biol Lipids, 1866(9), 158966. https://doi.org/10.1016/j.bbalip.2021.158966
Guan, Ziqiang, and Howard Goldfine. “Lipid diversity in clostridia.Biochim Biophys Acta Mol Cell Biol Lipids 1866, no. 9 (September 2021): 158966. https://doi.org/10.1016/j.bbalip.2021.158966.
Guan Z, Goldfine H. Lipid diversity in clostridia. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Sep;1866(9):158966.
Guan, Ziqiang, and Howard Goldfine. “Lipid diversity in clostridia.Biochim Biophys Acta Mol Cell Biol Lipids, vol. 1866, no. 9, Sept. 2021, p. 158966. Pubmed, doi:10.1016/j.bbalip.2021.158966.
Guan Z, Goldfine H. Lipid diversity in clostridia. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Sep;1866(9):158966.

Published In

Biochim Biophys Acta Mol Cell Biol Lipids

DOI

EISSN

1879-2618

Publication Date

September 2021

Volume

1866

Issue

9

Start / End Page

158966

Location

Netherlands

Related Subject Headings

  • Lipidomics
  • Clostridium
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences