The role of the extracellular matrix protein TGFBI in cancer.
The secreted extracellular protein, transforming growth factor beta induced (TGFBI or βIGH3), has roles in regulating numerous biological functions, including cell adhesion and bone formation, both during embryonic development and during the pathogenesis of human disease. TGFBI has been most studied in the context of hereditary corneal dystrophies, where mutations in TGFBI result in accumulation of TGFBI in the cornea. In cancer, early studies focused on TGFBI as a tumor suppressor, in part by promoting chemotherapy sensitivity. However, in established tumors, TGFBI largely has a role in promoting tumor progression, with elevated levels correlating to poorer clinical outcomes. As an important regulator of cancer progression, TGFBI expression and function is tightly regulated by numerous mechanisms including epigenetic silencing through promoter methylation and microRNAs. Mechanisms to target TGFBI have potential clinical utility in treating advanced cancers, while assessing TGFBI levels could be a biomarker for chemotherapy resistance and tumor progression.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- Transforming Growth Factor beta
- Neoplasms
- Humans
- Extracellular Matrix Proteins
- Epigenesis, Genetic
- Corneal Dystrophies, Hereditary
- Biochemistry & Molecular Biology
- 3101 Biochemistry and cell biology
- 1116 Medical Physiology
- 0601 Biochemistry and Cell Biology
Citation
Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- Transforming Growth Factor beta
- Neoplasms
- Humans
- Extracellular Matrix Proteins
- Epigenesis, Genetic
- Corneal Dystrophies, Hereditary
- Biochemistry & Molecular Biology
- 3101 Biochemistry and cell biology
- 1116 Medical Physiology
- 0601 Biochemistry and Cell Biology