Skip to main content
Journal cover image

Gut microbiome contributions to altered metabolism in a pig model of undernutrition.

Publication ,  Journal Article
Chang, H-W; McNulty, NP; Hibberd, MC; O'Donnell, D; Cheng, J; Lombard, V; Henrissat, B; Ilkayeva, O; Muehlbauer, MJ; Newgard, CB; Barratt, MJ ...
Published in: Proc Natl Acad Sci U S A
May 25, 2021

The concept that gut microbiome-expressed functions regulate ponderal growth has important implications for infant and child health, as well as animal health. Using an intergenerational pig model of diet restriction (DR) that produces reduced weight gain, we developed a feature-selection algorithm to identify representative characteristics distinguishing DR fecal microbiomes from those of full-fed (FF) pigs as both groups consumed a common sequence of diets during their growth cycle. Gnotobiotic mice were then colonized with DR and FF microbiomes and subjected to controlled feeding with a pig diet. DR microbiomes have reduced representation of genes that degrade dominant components of late growth-phase diets, exhibit reduced production of butyrate, a key host-accessible energy source, and are causally linked to reduced hepatic fatty acid metabolism (β-oxidation) and the selection of alternative energy substrates. The approach described could aid in the development of guidelines for microbiome stewardship in diverse species, including farm animals, in order to support their healthy growth.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

May 25, 2021

Volume

118

Issue

21

Location

United States

Related Subject Headings

  • alpha-Glucosidases
  • Taurocholic Acid
  • Swine
  • Sucrose
  • Starch
  • Phosphoric Monoester Hydrolases
  • Mice, Inbred C57BL
  • Mice
  • Malnutrition
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chang, H.-W., McNulty, N. P., Hibberd, M. C., O’Donnell, D., Cheng, J., Lombard, V., … Gordon, J. I. (2021). Gut microbiome contributions to altered metabolism in a pig model of undernutrition. Proc Natl Acad Sci U S A, 118(21). https://doi.org/10.1073/pnas.2024446118
Chang, Hao-Wei, Nathan P. McNulty, Matthew C. Hibberd, David O’Donnell, Jiye Cheng, Vincent Lombard, Bernard Henrissat, et al. “Gut microbiome contributions to altered metabolism in a pig model of undernutrition.Proc Natl Acad Sci U S A 118, no. 21 (May 25, 2021). https://doi.org/10.1073/pnas.2024446118.
Chang H-W, McNulty NP, Hibberd MC, O’Donnell D, Cheng J, Lombard V, et al. Gut microbiome contributions to altered metabolism in a pig model of undernutrition. Proc Natl Acad Sci U S A. 2021 May 25;118(21).
Chang, Hao-Wei, et al. “Gut microbiome contributions to altered metabolism in a pig model of undernutrition.Proc Natl Acad Sci U S A, vol. 118, no. 21, May 2021. Pubmed, doi:10.1073/pnas.2024446118.
Chang H-W, McNulty NP, Hibberd MC, O’Donnell D, Cheng J, Lombard V, Henrissat B, Ilkayeva O, Muehlbauer MJ, Newgard CB, Barratt MJ, Lin X, Odle J, Gordon JI. Gut microbiome contributions to altered metabolism in a pig model of undernutrition. Proc Natl Acad Sci U S A. 2021 May 25;118(21).
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

May 25, 2021

Volume

118

Issue

21

Location

United States

Related Subject Headings

  • alpha-Glucosidases
  • Taurocholic Acid
  • Swine
  • Sucrose
  • Starch
  • Phosphoric Monoester Hydrolases
  • Mice, Inbred C57BL
  • Mice
  • Malnutrition
  • Male