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Oncologic outcomes of minimally invasive versus open radical hysterectomy for early stage cervical carcinoma and tumor size <2 cm: a systematic review and meta-analysis.

Publication ,  Journal Article
Nasioudis, D; Albright, BB; Ko, EM; Haggerty, AF; Giuntoli Ii, RL; Kim, SH; Morgan, MA; Latif, NA
Published in: Int J Gynecol Cancer
July 2021

OBJECTIVE: To investigate the oncologic outcomes of patients with early-stage cervical carcinoma and tumor size <2 cm who underwent open or minimally invasive radical hysterectomy. METHODS: The Pubmed/Medline, Embase, and Web-of-Science databases were queried from inception to January 2021 (PROSPERO CRD 42020207971). Observational studies reporting progression-free survival and/or overall survival for patients who had open or minimally invasive radical hysterectomy for early-stage cervical carcinoma and tumor size <2 cm were selected. Level of statistical heterogeneity was evaluated with the I2 statistic. A random-effects model was used to compare progression and overall survival between the two groups and HR with 95% confidence intervals were calculated with the Der Simonian and Laird approach. Risk of bias and quality of included studies was assessed with the Newcastle-Ottawa scale. RESULTS: A total of 10 studies that met the inclusion criteria were included encompassing 4935 patients. Of these, 2394 (48.5%) patients had minimally invasive and 2541 (51.5%) patients had open radical hysterectomy; respectively. Patients who underwent minimally invasive hysterectomy had worse progression-free survival than those who had open surgery (HR 1.68, 95% CI 1.20, 2.36, I2 26%). Based on five studies, patients who had minimally invasive (n=1808) hysterectomy had a trend towards worse overall survival than those who had open surgery (n=1853) (HR 1.64, 95% CI 1.00 to 2.68, I2 15%). CONCLUSION: Based on a systematic review of the literature and meta-analysis of studies that control for confounders, for patients with cervical cancer and tumor size <2 cm, minimally invasive radical hysterectomy was associated with worse progression-free survival than laparotomy.

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Published In

Int J Gynecol Cancer

DOI

EISSN

1525-1438

Publication Date

July 2021

Volume

31

Issue

7

Start / End Page

983 / 990

Location

England

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Treatment Outcome
  • Progression-Free Survival
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Minimally Invasive Surgical Procedures
  • Hysterectomy
  • Humans
  • Female
  • 3211 Oncology and carcinogenesis
 

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Nasioudis, D., Albright, B. B., Ko, E. M., Haggerty, A. F., Giuntoli Ii, R. L., Kim, S. H., … Latif, N. A. (2021). Oncologic outcomes of minimally invasive versus open radical hysterectomy for early stage cervical carcinoma and tumor size <2 cm: a systematic review and meta-analysis. Int J Gynecol Cancer, 31(7), 983–990. https://doi.org/10.1136/ijgc-2021-002505
Nasioudis, Dimitrios, Benjamin B. Albright, Emily M. Ko, Ashley F. Haggerty, Robert L. Giuntoli Ii, Sarah H. Kim, Mark A. Morgan, and Nawar A. Latif. “Oncologic outcomes of minimally invasive versus open radical hysterectomy for early stage cervical carcinoma and tumor size <2 cm: a systematic review and meta-analysis.Int J Gynecol Cancer 31, no. 7 (July 2021): 983–90. https://doi.org/10.1136/ijgc-2021-002505.
Nasioudis D, Albright BB, Ko EM, Haggerty AF, Giuntoli Ii RL, Kim SH, et al. Oncologic outcomes of minimally invasive versus open radical hysterectomy for early stage cervical carcinoma and tumor size <2 cm: a systematic review and meta-analysis. Int J Gynecol Cancer. 2021 Jul;31(7):983–90.
Nasioudis, Dimitrios, et al. “Oncologic outcomes of minimally invasive versus open radical hysterectomy for early stage cervical carcinoma and tumor size <2 cm: a systematic review and meta-analysis.Int J Gynecol Cancer, vol. 31, no. 7, July 2021, pp. 983–90. Pubmed, doi:10.1136/ijgc-2021-002505.
Nasioudis D, Albright BB, Ko EM, Haggerty AF, Giuntoli Ii RL, Kim SH, Morgan MA, Latif NA. Oncologic outcomes of minimally invasive versus open radical hysterectomy for early stage cervical carcinoma and tumor size <2 cm: a systematic review and meta-analysis. Int J Gynecol Cancer. 2021 Jul;31(7):983–990.
Journal cover image

Published In

Int J Gynecol Cancer

DOI

EISSN

1525-1438

Publication Date

July 2021

Volume

31

Issue

7

Start / End Page

983 / 990

Location

England

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Treatment Outcome
  • Progression-Free Survival
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Minimally Invasive Surgical Procedures
  • Hysterectomy
  • Humans
  • Female
  • 3211 Oncology and carcinogenesis