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Moving geroscience from the bench to clinical care and health policy.

Publication ,  Journal Article
Sierra, F; Caspi, A; Fortinsky, RH; Haynes, L; Lithgow, GJ; Moffitt, TE; Olshansky, SJ; Perry, D; Verdin, E; Kuchel, GA
Published in: Journal of the American Geriatrics Society
September 2021

Geriatricians and others must embrace the emerging field of geroscience. Until recently geroscience research was pursued in laboratory animals, but now this field requires specialized expertise in the care of vulnerable older patients with multiple chronic diseases and geriatric syndromes, the population likely to benefit the most from emerging therapies. While chronological aging measures the inevitable passage of clock time that occurs equally for everyone, biological aging varies among individuals, and importantly, it is modifiable. Advances in our understanding of biological aging, the discovery of strategies for modifying its rate, and an appreciation of aging as a shared risk factor for chronic diseases have jointly led to the Geroscience Hypothesis. This hypothesis states that interventions modifying aging biology can slow its progression-resulting in the delay or prevention of the onset of multiple diseases and disorders. Here we wish to report on the Third Geroscience Summit held at National Institutes of Health on November 4-5, 2019, which highlighted the importance of engaging other disciplines including clinicians. Involvement by scientists with expertise in clinical trials, health outcomes research, behavioral and social sciences, health policy, and economics is urgently needed to translate geroscience discoveries from the bench to clinical care and health policy. Adding to the urgency of broadening this geroscience coalition is the emergence of biological aging as one the most important modifiable factors of COVID-19, combined with the inability of our society to once again recognize and confront aging as a priority and opportunity when facing these types of public health emergencies.

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Published In

Journal of the American Geriatrics Society

DOI

EISSN

1532-5415

ISSN

0002-8614

Publication Date

September 2021

Volume

69

Issue

9

Start / End Page

2455 / 2463

Related Subject Headings

  • SARS-CoV-2
  • Male
  • Humans
  • Health Policy
  • Geriatrics
  • Geriatrics
  • Female
  • Chronobiology Discipline
  • Chronic Disease
  • COVID-19
 

Citation

APA
Chicago
ICMJE
MLA
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Sierra, F., Caspi, A., Fortinsky, R. H., Haynes, L., Lithgow, G. J., Moffitt, T. E., … Kuchel, G. A. (2021). Moving geroscience from the bench to clinical care and health policy. Journal of the American Geriatrics Society, 69(9), 2455–2463. https://doi.org/10.1111/jgs.17301
Sierra, Felipe, Avshalom Caspi, Richard H. Fortinsky, Laura Haynes, Gordon J. Lithgow, Terrie E. Moffitt, S Jay Olshansky, Daniel Perry, Eric Verdin, and George A. Kuchel. “Moving geroscience from the bench to clinical care and health policy.Journal of the American Geriatrics Society 69, no. 9 (September 2021): 2455–63. https://doi.org/10.1111/jgs.17301.
Sierra F, Caspi A, Fortinsky RH, Haynes L, Lithgow GJ, Moffitt TE, et al. Moving geroscience from the bench to clinical care and health policy. Journal of the American Geriatrics Society. 2021 Sep;69(9):2455–63.
Sierra, Felipe, et al. “Moving geroscience from the bench to clinical care and health policy.Journal of the American Geriatrics Society, vol. 69, no. 9, Sept. 2021, pp. 2455–63. Epmc, doi:10.1111/jgs.17301.
Sierra F, Caspi A, Fortinsky RH, Haynes L, Lithgow GJ, Moffitt TE, Olshansky SJ, Perry D, Verdin E, Kuchel GA. Moving geroscience from the bench to clinical care and health policy. Journal of the American Geriatrics Society. 2021 Sep;69(9):2455–2463.
Journal cover image

Published In

Journal of the American Geriatrics Society

DOI

EISSN

1532-5415

ISSN

0002-8614

Publication Date

September 2021

Volume

69

Issue

9

Start / End Page

2455 / 2463

Related Subject Headings

  • SARS-CoV-2
  • Male
  • Humans
  • Health Policy
  • Geriatrics
  • Geriatrics
  • Female
  • Chronobiology Discipline
  • Chronic Disease
  • COVID-19