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Endovascular middle cerebral artery embolic stroke model: a novel approach.

Publication ,  Journal Article
Gonzalez, LF; Warner, DS; Sheng, H; Chaparro, E
Published in: J Neurointerv Surg
April 2022

A video (video 1) describing a novel murine endovascular embolic stroke model is presented. Traditional middle cerebral artery (MCA) occlusion models include a blind insertion of a monofilament string1 2 into the common or external carotid artery with the expectation to selectively occlude the MCA. However, significant mortality occurs due to subarachnoid hemorrhage and variability in stroke size, possibly related to the filament's malposition-for example, external carotid or proximal internal carotid artery (ICA). Additionally, while the string is in place, it occludes the entire extracranial ICA affecting also the collateral pial circulation. neurintsurg;14/4/413/V1F1V1Video 1 Our model includes tail artery access, which tolerates several procedures facilitating survival studies. This model uses autologous blood3 4 clot deployed directly into the MCA, resembling what occurs in clinical practice. Autologous thrombi could be lysed with IA/IV tissue plasminogen activator.In summary, we describe a novel model that resembles real practice, permits multiple catheterizations, results in reliable embolization under fluoroscopic guidance and allows therapeutic interventions not available with traditional models.

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Published In

J Neurointerv Surg

DOI

EISSN

1759-8486

Publication Date

April 2022

Volume

14

Issue

4

Start / End Page

413

Location

England

Related Subject Headings

  • Tissue Plasminogen Activator
  • Middle Cerebral Artery
  • Mice
  • Infarction, Middle Cerebral Artery
  • Humans
  • Endovascular Procedures
  • Embolic Stroke
  • Disease Models, Animal
  • Carotid Artery, Internal
  • Animals
 

Citation

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Gonzalez, L. F., Warner, D. S., Sheng, H., & Chaparro, E. (2022). Endovascular middle cerebral artery embolic stroke model: a novel approach. J Neurointerv Surg, 14(4), 413. https://doi.org/10.1136/neurintsurg-2021-017370
Gonzalez, L Fernando, David S. Warner, Huaxing Sheng, and Eduardo Chaparro. “Endovascular middle cerebral artery embolic stroke model: a novel approach.J Neurointerv Surg 14, no. 4 (April 2022): 413. https://doi.org/10.1136/neurintsurg-2021-017370.
Gonzalez LF, Warner DS, Sheng H, Chaparro E. Endovascular middle cerebral artery embolic stroke model: a novel approach. J Neurointerv Surg. 2022 Apr;14(4):413.
Gonzalez, L. Fernando, et al. “Endovascular middle cerebral artery embolic stroke model: a novel approach.J Neurointerv Surg, vol. 14, no. 4, Apr. 2022, p. 413. Pubmed, doi:10.1136/neurintsurg-2021-017370.
Gonzalez LF, Warner DS, Sheng H, Chaparro E. Endovascular middle cerebral artery embolic stroke model: a novel approach. J Neurointerv Surg. 2022 Apr;14(4):413.

Published In

J Neurointerv Surg

DOI

EISSN

1759-8486

Publication Date

April 2022

Volume

14

Issue

4

Start / End Page

413

Location

England

Related Subject Headings

  • Tissue Plasminogen Activator
  • Middle Cerebral Artery
  • Mice
  • Infarction, Middle Cerebral Artery
  • Humans
  • Endovascular Procedures
  • Embolic Stroke
  • Disease Models, Animal
  • Carotid Artery, Internal
  • Animals