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Infective endocarditis and solid organ transplantation: Only worse outcomes during initial transplantation hospitalization.

Publication ,  Journal Article
Eichenberger, EM; Dagher, M; Sinclair, MR; Maskarinec, SA; Fowler, VG; Federspiel, JJ
Published in: Am Heart J
October 2021

BACKGROUND: The epidemiology, and outcome of infective endocarditis (IE) among solid organ transplant (SOT) recipients is unknown. METHODS: We used data from the 2013-2018 Nationwide Readmissions Database (NRD). IE- and SOT-associated hospitalizations were identified using diagnosis and procedure codes. Outcomes included inpatient mortality, length of stay, and inpatient costs. Adjusted analyses were performed using weighted regression models. RESULTS: A total of 99,052 IE-associated hospitalizations, corresponding to a weighted national estimate of 193,164, were included for analysis. Of these, 794 (weighted n = 1,574) were associated with transplant history (SOT-IE). Mortality was not significantly different between SOT-IE and non-SOT-IE (17.2% vs. 15.8%, adjusted relative risk [aRR]: 0.86, 95% confidence interval [CI] [0.71, 1.03]), and fewer SOT-IE patients underwent valve repair or replacement than non-SOT-IE (12.5% vs. 16.2%, aRR 0.82, 95% CI [0.71, 0.95]). We then compared outcomes of patients diagnosed with IE during their index transplant hospitalization (index-SOT-IE) to patients without IE during their transplant hospitalization (index-SOT). Index-SOT-IE occurred most frequently among heart transplant recipients (45.1%), and was associated with greater mortality (27.1% vs. 2.3%, aRR 6.07, 95% CI [3.32, 11.11]). CONCLUSION: Dual diagnosis of SOT and IE was associated with worse outcomes among SOT recipients during index hospitalization, but not overall among patients with IE.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

October 2021

Volume

240

Start / End Page

63 / 72

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Risk Factors
  • Retrospective Studies
  • Regression Analysis
  • Postoperative Complications
  • Organ Transplantation
  • Middle Aged
  • Male
  • Length of Stay
 

Citation

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Eichenberger, E. M., Dagher, M., Sinclair, M. R., Maskarinec, S. A., Fowler, V. G., & Federspiel, J. J. (2021). Infective endocarditis and solid organ transplantation: Only worse outcomes during initial transplantation hospitalization. Am Heart J, 240, 63–72. https://doi.org/10.1016/j.ahj.2021.06.007
Eichenberger, Emily M., Michael Dagher, Matthew R. Sinclair, Stacey A. Maskarinec, Vance G. Fowler, and Jerome J. Federspiel. “Infective endocarditis and solid organ transplantation: Only worse outcomes during initial transplantation hospitalization.Am Heart J 240 (October 2021): 63–72. https://doi.org/10.1016/j.ahj.2021.06.007.
Eichenberger EM, Dagher M, Sinclair MR, Maskarinec SA, Fowler VG, Federspiel JJ. Infective endocarditis and solid organ transplantation: Only worse outcomes during initial transplantation hospitalization. Am Heart J. 2021 Oct;240:63–72.
Eichenberger, Emily M., et al. “Infective endocarditis and solid organ transplantation: Only worse outcomes during initial transplantation hospitalization.Am Heart J, vol. 240, Oct. 2021, pp. 63–72. Pubmed, doi:10.1016/j.ahj.2021.06.007.
Eichenberger EM, Dagher M, Sinclair MR, Maskarinec SA, Fowler VG, Federspiel JJ. Infective endocarditis and solid organ transplantation: Only worse outcomes during initial transplantation hospitalization. Am Heart J. 2021 Oct;240:63–72.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

October 2021

Volume

240

Start / End Page

63 / 72

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Risk Factors
  • Retrospective Studies
  • Regression Analysis
  • Postoperative Complications
  • Organ Transplantation
  • Middle Aged
  • Male
  • Length of Stay