Differential modulation of polyunsaturated fatty acids in patients with myocardial infarction treated with ticagrelor or clopidogrel.
Untargeted metabolomics is used to refine the development of biomarkers for the diagnosis of cardiovascular disease. Myocardial infarction (MI) has major individual and societal consequences for patients, who remain at high risk of secondary events, despite advances in pharmacological therapy. To monitor their differential response to treatment, we performed untargeted plasma metabolomics on 175 patients from the platelet inhibition and patient outcomes (PLATO) trial treated with ticagrelor and clopidogrel, two common P2Y12 inhibitors. We identified a signature that discriminates patients, which involves polyunsaturated fatty acids (PUFAs) and particularly the omega-3 fatty acids docosahexaenoate and eicosapentaenoate. The known cardiovascular benefits of PUFAs could contribute to the efficacy of ticagrelor. Our work, beyond pointing out the high relevance of untargeted metabolomics in evaluating response to treatment, establishes PUFA metabolism as a pathway of clinical interest in the recovery path from MI.
Duke Scholars
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Related Subject Headings
- Treatment Outcome
- Ticagrelor
- Purinergic P2Y Receptor Antagonists
- Platelet Aggregation Inhibitors
- Myocardial Infarction
- Middle Aged
- Metabolomics
- Male
- Lipid Metabolism
- Humans
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Treatment Outcome
- Ticagrelor
- Purinergic P2Y Receptor Antagonists
- Platelet Aggregation Inhibitors
- Myocardial Infarction
- Middle Aged
- Metabolomics
- Male
- Lipid Metabolism
- Humans