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A Pilot Study of Associations Between Visceral Fat, IL-6, and Urinary F2-Isoprostanes in Older Adults Exposed to a Diet Intervention.

Publication ,  Journal Article
Hoover, SE; Il'yasova, D; Fontaine, KR; Spasojevic, I; Gower, BA; Goss, AM
Published in: Curr Dev Nutr
June 2021

BACKGROUND: Short-term markers of successful visceral adipose tissue (VAT) loss are needed. Urinary F2-isoprostanes might serve as a marker for intensified lipid metabolism, whereas circulating IL-6 might stimulate fat oxidation and enhance mobilization of VAT. OBJECTIVES: This pilot study was designed to explore the hypotheses that 1) reduction in VAT is associated with increase in IL-6, and 2) that increases in urinary F2-isoprostanes are associated with increases in IL-6 and reduction in VAT. METHODS: Eighteen participants (aged 60-75 y, BMI 30-40 kg/m2) were randomly assigned to either a very-low-carbohydrate diet (VLCD; <10:25:>65% energy from carbohydrate:protein:fat) or a low-fat diet (LFD; 55:25:20%) for 8 wk. Changes in fat distribution were assessed by MRI. Four urinary F2-isoprostane isomers were quantified in 24-h urine collection using LC-MS/MS analyses. Changes in 4 F2-isoprostane isomers were summarized using factor analysis (Δ-F2-isoprostane factor). Statistical significance was set at P < 0.1. RESULTS: Within the VLCD group, change in VAT was inversely associated with change in IL-6 (r = -0.778, P = 0.069) and Δ-F2-isoprostane factor (r = -0.690, P = 0.086), demonstrating that participants who maintained higher concentrations of F2-isoprostane factor across the intervention showed greater decreases in VAT. A positive relation between Δ-F2-isoprostane factor and change in IL-6 was observed (r = 0.642, P = 0.062). In the LFD group, no significant associations between changes in VAT, F2-isoprostane factor, or IL-6 were observed. CONCLUSIONS: Results from this exploratory study in older adults with obesity suggest that, in the context of a VLCD, IL-6 could be involved in VAT mobilization, and urinary F2-isoprostanes could reflect intensified oxidation of mobilized fatty acids.Trial registration: This study is registered at clinicaltrials.gov as NCT02760641.

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Published In

Curr Dev Nutr

DOI

EISSN

2475-2991

Publication Date

June 2021

Volume

5

Issue

6

Start / End Page

nzab082

Location

United States

Related Subject Headings

  • 3210 Nutrition and dietetics
  • 3006 Food sciences
  • 3003 Animal production
 

Citation

APA
Chicago
ICMJE
MLA
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Hoover, S. E., Il’yasova, D., Fontaine, K. R., Spasojevic, I., Gower, B. A., & Goss, A. M. (2021). A Pilot Study of Associations Between Visceral Fat, IL-6, and Urinary F2-Isoprostanes in Older Adults Exposed to a Diet Intervention. Curr Dev Nutr, 5(6), nzab082. https://doi.org/10.1093/cdn/nzab082
Hoover, Sarah E., Dora Il’yasova, Kevin R. Fontaine, Ivan Spasojevic, Barbara A. Gower, and Amy M. Goss. “A Pilot Study of Associations Between Visceral Fat, IL-6, and Urinary F2-Isoprostanes in Older Adults Exposed to a Diet Intervention.Curr Dev Nutr 5, no. 6 (June 2021): nzab082. https://doi.org/10.1093/cdn/nzab082.
Hoover SE, Il’yasova D, Fontaine KR, Spasojevic I, Gower BA, Goss AM. A Pilot Study of Associations Between Visceral Fat, IL-6, and Urinary F2-Isoprostanes in Older Adults Exposed to a Diet Intervention. Curr Dev Nutr. 2021 Jun;5(6):nzab082.
Hoover, Sarah E., et al. “A Pilot Study of Associations Between Visceral Fat, IL-6, and Urinary F2-Isoprostanes in Older Adults Exposed to a Diet Intervention.Curr Dev Nutr, vol. 5, no. 6, June 2021, p. nzab082. Pubmed, doi:10.1093/cdn/nzab082.
Hoover SE, Il’yasova D, Fontaine KR, Spasojevic I, Gower BA, Goss AM. A Pilot Study of Associations Between Visceral Fat, IL-6, and Urinary F2-Isoprostanes in Older Adults Exposed to a Diet Intervention. Curr Dev Nutr. 2021 Jun;5(6):nzab082.

Published In

Curr Dev Nutr

DOI

EISSN

2475-2991

Publication Date

June 2021

Volume

5

Issue

6

Start / End Page

nzab082

Location

United States

Related Subject Headings

  • 3210 Nutrition and dietetics
  • 3006 Food sciences
  • 3003 Animal production