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Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia.

Publication ,  Journal Article
Bahrani, AA; Smith, CD; Barber, JM; Al-Janabi, OM; Powell, DK; Andersen, AH; Ramey, BD; Abner, EL; Goldstein, LB; Winder, Z; Gold, BT ...
Published in: J Neurosci Methods
August 1, 2021

BACKGROUND: White matter hyperintensities (WMH), associated with both dementia risk and progression, can individually progress, remain stable, or even regress influencing cognitive decline related to specific cerebrovascular-risks. This study details the development and validation of a registration protocol to assess regional, within-subject, longitudinal WMH changes (ΔWMH) that is currently lacking in the field. NEW METHOD: 3D-FLAIR images (baseline and one-year-visit) were used for protocol development and validation. The method was validated by assessing the correlation between forward and reverse longitudinal registration, and between summated regional progression-regression volumes and Global ΔWMH. The clinical relevance of growth-regression ΔWMH were explored in relation to an executive function test. RESULTS: MRI scans for 79 participants (73.5 ± 8.8 years) were used in this study. Global ΔWMH vs. summated regional progression-regression volumes were highly associated (r2 = 0.90; p-value < 0.001). Bi-directional registration validated the registration method (r2 = 0.999; p-value < 0.001). Growth and regression, but not overall ΔWMH, were associated with one-year declines in performance on Trial-Making-Test-B. COMPARISON WITH EXISTING METHOD(S): This method presents a unique registration protocol for maximum tissue alignment, demonstrating three distinct patterns of longitudinal within-subject ΔWMH (stable, growth and regression). CONCLUSIONS: These data detail the development and validation of a registration protocol for use in assessing within-subject, voxel-level alterations in WMH volume. The methods developed for registration and intensity correction of longitudinal within-subject FLAIR images allow regional and within-lesion characterization of longitudinal ΔWMH. Assessing the impact of associated cerebrovascular-risks and longitudinal clinical changes in relation to dynamic regional ΔWMH is needed in future studies.

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Published In

J Neurosci Methods

DOI

EISSN

1872-678X

Publication Date

August 1, 2021

Volume

360

Start / End Page

109270

Location

Netherlands

Related Subject Headings

  • White Matter
  • Neurology & Neurosurgery
  • Magnetic Resonance Imaging
  • Humans
  • Dementia
  • Cognitive Dysfunction
  • Aging
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1701 Psychology
 

Citation

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MLA
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Bahrani, A. A., Smith, C. D., Barber, J. M., Al-Janabi, O. M., Powell, D. K., Andersen, A. H., … Jicha, G. A. (2021). Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia. J Neurosci Methods, 360, 109270. https://doi.org/10.1016/j.jneumeth.2021.109270
Bahrani, Ahmed A., Charles D. Smith, Justin M. Barber, Omar M. Al-Janabi, David K. Powell, Anders H. Andersen, Brandon D. Ramey, et al. “Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia.J Neurosci Methods 360 (August 1, 2021): 109270. https://doi.org/10.1016/j.jneumeth.2021.109270.
Bahrani AA, Smith CD, Barber JM, Al-Janabi OM, Powell DK, Andersen AH, et al. Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia. J Neurosci Methods. 2021 Aug 1;360:109270.
Bahrani, Ahmed A., et al. “Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia.J Neurosci Methods, vol. 360, Aug. 2021, p. 109270. Pubmed, doi:10.1016/j.jneumeth.2021.109270.
Bahrani AA, Smith CD, Barber JM, Al-Janabi OM, Powell DK, Andersen AH, Ramey BD, Abner EL, Goldstein LB, Winder Z, Gold BT, Van Eldik L, Wilcock DM, Jicha GA. Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia. J Neurosci Methods. 2021 Aug 1;360:109270.
Journal cover image

Published In

J Neurosci Methods

DOI

EISSN

1872-678X

Publication Date

August 1, 2021

Volume

360

Start / End Page

109270

Location

Netherlands

Related Subject Headings

  • White Matter
  • Neurology & Neurosurgery
  • Magnetic Resonance Imaging
  • Humans
  • Dementia
  • Cognitive Dysfunction
  • Aging
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1701 Psychology