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Genetic variants of EML1 and HIST1H4E in myeloid cell-related pathway genes independently predict cutaneous melanoma-specific survival.

Publication ,  Journal Article
He, Y; Liu, H; Luo, S; Amos, CI; Lee, JE; Yang, K; Qureshi, AA; Han, J; Wei, Q
Published in: Am J Cancer Res
2021

UNLABELLED: Both in vivo and in vitro evidence has supported a key role of myeloid cells in immune suppression in melanoma and in promoting melanocytic metastases. Some single-nucleotide polymorphisms (SNPs) have been shown to predict cutaneous melanoma-specific survival (CMSS), but the association between genetic variation in myeloid cell-related genes and cutaneous melanoma (CM) patient survival remains unknown. METHODS: we investigated associations between SNPs in myeloid cell-related pathway genes and CMSS in a discovery dataset of 850 CM patients and replicated the findings in another dataset of 409 CM patients. RESULTS: we identified two SNPs (EML1 rs10151787 A>G and HIST1H4E rs2069018 T>C) as independent prognostic factors for CMSS, with adjusted allelic hazards ratios of 1.56 (95% confidence interval =1.19-2.05, P=0.001) and 1.66 (1.22-2.26, P=0.001), respectively; so were their combined unfavorable alleles in a dose-response manner in both discovery and replication datasets (P trend<0.001 and 0.002, respectively). Additional functional analysis revealed that both EML1 rs10151787 G and HIST1H4E rs2069018 C alleles were associated with elevated mRNA expression levels in normal tissues. CONCLUSIONS: Our findings suggest that EML1 rs10151787 A>G and HIST1H4E rs2069018 T>C are independent prognostic biomarkers for CMSS.

Duke Scholars

Published In

Am J Cancer Res

ISSN

2156-6976

Publication Date

2021

Volume

11

Issue

6

Start / End Page

3252 / 3262

Location

United States

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
He, Y., Liu, H., Luo, S., Amos, C. I., Lee, J. E., Yang, K., … Wei, Q. (2021). Genetic variants of EML1 and HIST1H4E in myeloid cell-related pathway genes independently predict cutaneous melanoma-specific survival. Am J Cancer Res, 11(6), 3252–3262.
He, Yuanmin, Hongliang Liu, Sheng Luo, Christopher I. Amos, Jeffrey E. Lee, Keming Yang, Abrar A. Qureshi, Jiali Han, and Qingyi Wei. “Genetic variants of EML1 and HIST1H4E in myeloid cell-related pathway genes independently predict cutaneous melanoma-specific survival.Am J Cancer Res 11, no. 6 (2021): 3252–62.
He Y, Liu H, Luo S, Amos CI, Lee JE, Yang K, et al. Genetic variants of EML1 and HIST1H4E in myeloid cell-related pathway genes independently predict cutaneous melanoma-specific survival. Am J Cancer Res. 2021;11(6):3252–62.
He Y, Liu H, Luo S, Amos CI, Lee JE, Yang K, Qureshi AA, Han J, Wei Q. Genetic variants of EML1 and HIST1H4E in myeloid cell-related pathway genes independently predict cutaneous melanoma-specific survival. Am J Cancer Res. 2021;11(6):3252–3262.

Published In

Am J Cancer Res

ISSN

2156-6976

Publication Date

2021

Volume

11

Issue

6

Start / End Page

3252 / 3262

Location

United States

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis