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Each patient is a research biorepository: informatics-enabled research on surplus clinical specimens via the living BioBank.

Publication ,  Journal Article
Alekseyenko, AV; Hamidi, B; Faith, TD; Crandall, KA; Powers, JG; Metts, CL; Madory, JE; Carroll, SL; Obeid, JS; Lenert, LA
Published in: J Am Med Inform Assoc
January 15, 2021

The ability to analyze human specimens is the pillar of modern-day translational research. To enhance the research availability of relevant clinical specimens, we developed the Living BioBank (LBB) solution, which allows for just-in-time capture and delivery of phenotyped surplus laboratory medicine specimens. The LBB is a system-of-systems integrating research feasibility databases in i2b2, a real-time clinical data warehouse, and an informatics system for institutional research services management (SPARC). LBB delivers deidentified clinical data and laboratory specimens. We further present an extension to our solution, the Living µBiome Bank, that allows the user to request and receive phenotyped specimen microbiome data. We discuss the details of the implementation of the LBB system and the necessary regulatory oversight for this solution. The conducted institutional focus group of translational investigators indicates an overall positive sentiment towards potential scientific results generated with the use of LBB. Reference implementation of LBB is available at https://LivingBioBank.musc.edu.

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Published In

J Am Med Inform Assoc

DOI

EISSN

1527-974X

Publication Date

January 15, 2021

Volume

28

Issue

1

Start / End Page

138 / 143

Location

England

Related Subject Headings

  • Translational Research, Biomedical
  • Surveys and Questionnaires
  • Phenotype
  • Microbiota
  • Medical Informatics
  • Humans
  • Databases, Factual
  • Data Warehousing
  • Biological Specimen Banks
  • 46 Information and computing sciences
 

Citation

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Alekseyenko, A. V., Hamidi, B., Faith, T. D., Crandall, K. A., Powers, J. G., Metts, C. L., … Lenert, L. A. (2021). Each patient is a research biorepository: informatics-enabled research on surplus clinical specimens via the living BioBank. J Am Med Inform Assoc, 28(1), 138–143. https://doi.org/10.1093/jamia/ocaa236
Alekseyenko, Alexander V., Bashir Hamidi, Trevor D. Faith, Keith A. Crandall, Jennifer G. Powers, Christopher L. Metts, James E. Madory, Steven L. Carroll, Jihad S. Obeid, and Leslie A. Lenert. “Each patient is a research biorepository: informatics-enabled research on surplus clinical specimens via the living BioBank.J Am Med Inform Assoc 28, no. 1 (January 15, 2021): 138–43. https://doi.org/10.1093/jamia/ocaa236.
Alekseyenko AV, Hamidi B, Faith TD, Crandall KA, Powers JG, Metts CL, et al. Each patient is a research biorepository: informatics-enabled research on surplus clinical specimens via the living BioBank. J Am Med Inform Assoc. 2021 Jan 15;28(1):138–43.
Alekseyenko, Alexander V., et al. “Each patient is a research biorepository: informatics-enabled research on surplus clinical specimens via the living BioBank.J Am Med Inform Assoc, vol. 28, no. 1, Jan. 2021, pp. 138–43. Pubmed, doi:10.1093/jamia/ocaa236.
Alekseyenko AV, Hamidi B, Faith TD, Crandall KA, Powers JG, Metts CL, Madory JE, Carroll SL, Obeid JS, Lenert LA. Each patient is a research biorepository: informatics-enabled research on surplus clinical specimens via the living BioBank. J Am Med Inform Assoc. 2021 Jan 15;28(1):138–143.
Journal cover image

Published In

J Am Med Inform Assoc

DOI

EISSN

1527-974X

Publication Date

January 15, 2021

Volume

28

Issue

1

Start / End Page

138 / 143

Location

England

Related Subject Headings

  • Translational Research, Biomedical
  • Surveys and Questionnaires
  • Phenotype
  • Microbiota
  • Medical Informatics
  • Humans
  • Databases, Factual
  • Data Warehousing
  • Biological Specimen Banks
  • 46 Information and computing sciences