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Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease.

Publication ,  Journal Article
Hu, WT; Ozturk, T; Kollhoff, A; Wharton, W; Christina Howell, J; Alzheimer’s Disease Neuroimaging Initiative,
Published in: Nat Commun
June 28, 2021

Neuroinflammation is associated with Alzheimer's disease, but the application of cerebrospinal fluid measures of inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 cerebrospinal proteins related to microglial and T-cell functions, and show them to reproducibly form functionally-related groups within and across diagnostic categories in 382 participants from the Alzheimer's Disease Neuro-imaging Initiative as well participants from two independent cohorts. We further show higher levels of proteins related to soluble tumor necrosis factor receptor 1 are associated with reduced risk of conversion to dementia in the multi-centered (p = 0.027) and independent (p = 0.038) cohorts of people with mild cognitive impairment due to predicted Alzheimer's disease, while higher soluble TREM2 levels associated with slower decline in the dementia stage of Alzheimer's disease. These inflammatory proteins thus provide prognostic information independent of established Alzheimer's markers.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

June 28, 2021

Volume

12

Issue

1

Start / End Page

4001

Location

England

Related Subject Headings

  • tau Proteins
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Immunologic
  • Prognosis
  • Peptide Fragments
  • Membrane Glycoproteins
  • Male
  • Humans
  • Female
  • Cognitive Dysfunction
 

Citation

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Hu, W. T., Ozturk, T., Kollhoff, A., Wharton, W., Christina Howell, J., & Alzheimer’s Disease Neuroimaging Initiative, . (2021). Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease. Nat Commun, 12(1), 4001. https://doi.org/10.1038/s41467-021-24220-7
Hu, William T., Tugba Ozturk, Alexander Kollhoff, Whitney Wharton, J. Christina Howell, and J. Alzheimer’s Disease Neuroimaging Initiative. “Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease.Nat Commun 12, no. 1 (June 28, 2021): 4001. https://doi.org/10.1038/s41467-021-24220-7.
Hu WT, Ozturk T, Kollhoff A, Wharton W, Christina Howell J, Alzheimer’s Disease Neuroimaging Initiative. Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease. Nat Commun. 2021 Jun 28;12(1):4001.
Hu, William T., et al. “Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease.Nat Commun, vol. 12, no. 1, June 2021, p. 4001. Pubmed, doi:10.1038/s41467-021-24220-7.
Hu WT, Ozturk T, Kollhoff A, Wharton W, Christina Howell J, Alzheimer’s Disease Neuroimaging Initiative. Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease. Nat Commun. 2021 Jun 28;12(1):4001.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

June 28, 2021

Volume

12

Issue

1

Start / End Page

4001

Location

England

Related Subject Headings

  • tau Proteins
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Immunologic
  • Prognosis
  • Peptide Fragments
  • Membrane Glycoproteins
  • Male
  • Humans
  • Female
  • Cognitive Dysfunction