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Impact of ozone exposure on heart rate variability and stress hormones: A randomized-crossover study.

Publication ,  Journal Article
Wang, C; Lin, J; Niu, Y; Wang, W; Wen, J; Lv, L; Liu, C; Du, X; Zhang, Q; Chen, B; Cai, J; Zhao, Z; Liang, D; Ji, JS; Chen, H; Chen, R; Kan, H
Published in: Journal of hazardous materials
January 2022

The biological mechanisms underlying the associations between atmospheric ozone exposure and adverse cardiometabolic outcomes are yet to be identified. Imbalanced autonomic nervous system (ANS) as well as activations of the sympatho-adrenomedullary (SAM) and hypothalamic-pituitary-adrenal (HPA) axes are among possible early biological responses triggered by ozone, and may eventually lead to cardiometabolic abnormalities. To determine whether acute ozone exposure causes ANS imbalance and increases the secretion of neuroendocrine stress hormones, we conducted a randomized, double-blind, crossover trial, under controlled 2-hour exposure to either ozone (200 ppb) or clean air with intermittent exercise among 22 healthy young adults. Here we found that, compared to clean air exposure, acute ozone exposure significantly decreased the high-frequency band of heart rate variability, even after adjusting for heart rate and pre-exposure to ambient air pollutants and meteorological factors. Ozone exposure also significantly increased the serum levels of stress hormones, including corticotrophin-releasing factor, adrenocorticotropic hormone, adrenaline, and noradrenaline. Metabolomics analysis showed that acute ozone exposure led to alterations in stress hormones, systemic inflammation, oxidative stress, and energy metabolism. Our results suggest that acute ozone exposure may trigger ANS imbalance and activate the HPA and SAM axes, offering potential biological explanations for the adverse cardiometabolic effects following acute ozone exposure.

Duke Scholars

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Published In

Journal of hazardous materials

DOI

EISSN

1873-3336

ISSN

0304-3894

Publication Date

January 2022

Volume

421

Start / End Page

126750

Related Subject Headings

  • Young Adult
  • Strategic, Defence & Security Studies
  • Ozone
  • Humans
  • Hormones
  • Heart Rate
  • Cross-Over Studies
  • Air Pollutants
  • 41 Environmental sciences
  • 40 Engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, C., Lin, J., Niu, Y., Wang, W., Wen, J., Lv, L., … Kan, H. (2022). Impact of ozone exposure on heart rate variability and stress hormones: A randomized-crossover study. Journal of Hazardous Materials, 421, 126750. https://doi.org/10.1016/j.jhazmat.2021.126750
Wang, Cuiping, Jingyu Lin, Yue Niu, Weidong Wang, Jianfen Wen, Lili Lv, Cong Liu, et al. “Impact of ozone exposure on heart rate variability and stress hormones: A randomized-crossover study.Journal of Hazardous Materials 421 (January 2022): 126750. https://doi.org/10.1016/j.jhazmat.2021.126750.
Wang C, Lin J, Niu Y, Wang W, Wen J, Lv L, et al. Impact of ozone exposure on heart rate variability and stress hormones: A randomized-crossover study. Journal of hazardous materials. 2022 Jan;421:126750.
Wang, Cuiping, et al. “Impact of ozone exposure on heart rate variability and stress hormones: A randomized-crossover study.Journal of Hazardous Materials, vol. 421, Jan. 2022, p. 126750. Epmc, doi:10.1016/j.jhazmat.2021.126750.
Wang C, Lin J, Niu Y, Wang W, Wen J, Lv L, Liu C, Du X, Zhang Q, Chen B, Cai J, Zhao Z, Liang D, Ji JS, Chen H, Chen R, Kan H. Impact of ozone exposure on heart rate variability and stress hormones: A randomized-crossover study. Journal of hazardous materials. 2022 Jan;421:126750.
Journal cover image

Published In

Journal of hazardous materials

DOI

EISSN

1873-3336

ISSN

0304-3894

Publication Date

January 2022

Volume

421

Start / End Page

126750

Related Subject Headings

  • Young Adult
  • Strategic, Defence & Security Studies
  • Ozone
  • Humans
  • Hormones
  • Heart Rate
  • Cross-Over Studies
  • Air Pollutants
  • 41 Environmental sciences
  • 40 Engineering