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Results and interpretation of a fitting challenge for MR spectroscopy set up by the MRS study group of ISMRM.

Publication ,  Journal Article
Marjańska, M; Deelchand, DK; Kreis, R; 2016 ISMRM MRS Study Group Fitting Challenge Team,
Published in: Magn Reson Med
January 2022

PURPOSE: Fitting of MRS data plays an important role in the quantification of metabolite concentrations. Many different spectral fitting packages are used by the MRS community. A fitting challenge was set up to allow comparison of fitting methods on the basis of performance and robustness. METHODS: Synthetic data were generated for 28 datasets. Short-echo time PRESS spectra were simulated using ideal pulses for the common metabolites at mostly near-normal brain concentrations. Macromolecular contributions were also included. Modulations of signal-to-noise ratio (SNR); lineshape type and width; concentrations of γ-aminobutyric acid, glutathione, and macromolecules; and inclusion of artifacts and lipid signals to mimic tumor spectra were included as challenges to be coped with. RESULTS: Twenty-six submissions were evaluated. Visually, most fit packages performed well with mostly noise-like residuals. However, striking differences in fit performance were found with bias problems also evident for well-known packages. In addition, often error bounds were not appropriately estimated and deduced confidence limits misleading. Soft constraints as used in LCModel were found to substantially influence the fitting results and their dependence on SNR. CONCLUSIONS: Substantial differences were found for accuracy and precision of fit results obtained by the multiple fit packages.

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Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

January 2022

Volume

87

Issue

1

Start / End Page

11 / 32

Location

United States

Related Subject Headings

  • Signal-To-Noise Ratio
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Spectroscopy
  • Macromolecular Substances
  • Brain
  • Artifacts
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
 

Citation

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ICMJE
MLA
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Marjańska, M., Deelchand, D. K., Kreis, R., & 2016 ISMRM MRS Study Group Fitting Challenge Team, . (2022). Results and interpretation of a fitting challenge for MR spectroscopy set up by the MRS study group of ISMRM. Magn Reson Med, 87(1), 11–32. https://doi.org/10.1002/mrm.28942
Marjańska, Małgorzata, Dinesh K. Deelchand, Roland Kreis, and Roland 2016 ISMRM MRS Study Group Fitting Challenge Team. “Results and interpretation of a fitting challenge for MR spectroscopy set up by the MRS study group of ISMRM.Magn Reson Med 87, no. 1 (January 2022): 11–32. https://doi.org/10.1002/mrm.28942.
Marjańska M, Deelchand DK, Kreis R, 2016 ISMRM MRS Study Group Fitting Challenge Team. Results and interpretation of a fitting challenge for MR spectroscopy set up by the MRS study group of ISMRM. Magn Reson Med. 2022 Jan;87(1):11–32.
Marjańska, Małgorzata, et al. “Results and interpretation of a fitting challenge for MR spectroscopy set up by the MRS study group of ISMRM.Magn Reson Med, vol. 87, no. 1, Jan. 2022, pp. 11–32. Pubmed, doi:10.1002/mrm.28942.
Marjańska M, Deelchand DK, Kreis R, 2016 ISMRM MRS Study Group Fitting Challenge Team. Results and interpretation of a fitting challenge for MR spectroscopy set up by the MRS study group of ISMRM. Magn Reson Med. 2022 Jan;87(1):11–32.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

January 2022

Volume

87

Issue

1

Start / End Page

11 / 32

Location

United States

Related Subject Headings

  • Signal-To-Noise Ratio
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Spectroscopy
  • Macromolecular Substances
  • Brain
  • Artifacts
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering