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Neural signatures of saliency-mapping in anhedonia: A narrative review.

Publication ,  Journal Article
Pisoni, A; Davis, SW; Smoski, M
Published in: Psychiatry Res
October 2021

Anhedonia is the loss of pleasure or motivation to engage in previously enjoyable activities, and is a transdiagnostic symptom associated with significant clinical impairment. Anhedonia is implicated in several different psychiatric disorders, presenting a promising opportunity for transdiagnostic treatment. Thus, developing targeted treatments for anhedonia is of critical importance for population mental health. An important first step in doing so is establishing a thorough understanding of the neural correlates of anhedonia. The Triple Network Model of Psychopathology provides a frame for how brain activity may go awry in anhedonia, specifically in the context of Salience Network (SN) function (i.e., saliency-mapping). We present a narrative review examining saliency-mapping as it relates to anhedonia severity in depressed and transdiagnostic adult samples. Results revealed increased anhedonia to be associated with hyperactivity of the SN at rest and in the context of negative stimuli, as well as a global lack of SN engagement in the context of positive stimuli. Potential treatments for anhedonia are placed within this model, and future directions for research are discussed.

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Published In

Psychiatry Res

DOI

EISSN

1872-7123

Publication Date

October 2021

Volume

304

Start / End Page

114123

Location

Ireland

Related Subject Headings

  • Reward
  • Psychiatry
  • Pleasure
  • Motivation
  • Magnetic Resonance Imaging
  • Humans
  • Anhedonia
  • Adult
  • 5203 Clinical and health psychology
  • 3202 Clinical sciences
 

Citation

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Pisoni, A., Davis, S. W., & Smoski, M. (2021). Neural signatures of saliency-mapping in anhedonia: A narrative review. Psychiatry Res, 304, 114123. https://doi.org/10.1016/j.psychres.2021.114123
Pisoni, Angela, Simon W. Davis, and Moria Smoski. “Neural signatures of saliency-mapping in anhedonia: A narrative review.Psychiatry Res 304 (October 2021): 114123. https://doi.org/10.1016/j.psychres.2021.114123.
Pisoni A, Davis SW, Smoski M. Neural signatures of saliency-mapping in anhedonia: A narrative review. Psychiatry Res. 2021 Oct;304:114123.
Pisoni, Angela, et al. “Neural signatures of saliency-mapping in anhedonia: A narrative review.Psychiatry Res, vol. 304, Oct. 2021, p. 114123. Pubmed, doi:10.1016/j.psychres.2021.114123.
Pisoni A, Davis SW, Smoski M. Neural signatures of saliency-mapping in anhedonia: A narrative review. Psychiatry Res. 2021 Oct;304:114123.
Journal cover image

Published In

Psychiatry Res

DOI

EISSN

1872-7123

Publication Date

October 2021

Volume

304

Start / End Page

114123

Location

Ireland

Related Subject Headings

  • Reward
  • Psychiatry
  • Pleasure
  • Motivation
  • Magnetic Resonance Imaging
  • Humans
  • Anhedonia
  • Adult
  • 5203 Clinical and health psychology
  • 3202 Clinical sciences