Skip to main content
Journal cover image

Rationale and design of the Prone Position and Respiratory Outcomes in Non-intubated COVID-19 PatiEnts: The "PRONE" Study.

Publication ,  Journal Article
Friedman, E; Franzone, J; Ko, ER; Corey, K; Mock, J; Alavian, N; Schwartz, A; Drummond, MB; Suber, T; Linstrum, K; Bain, W; Castiblanco, SA ...
Published in: Contemp Clin Trials
October 2021

While benefits of prone position in mechanically-ventilated patients have been well-described, a randomized-control trial to determine the effects of prone positioning in awake, spontaneously-breathing patients with an acute pneumonia has not been previously conducted. Prone Position and Respiratory Outcomes in Non-Intubated COVID-19 PatiEnts: the "PRONE" Study (PRONE) was conducted in non-intubated hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia as defined by respiratory rate ≥ 20/min or an oxyhemoglobin saturation (SpO2) ≤ 93% without supplemental oxygen [1]. The PRONE trial was designed to investigate the effects of prone positioning on need for escalation in respiratory support, as defined by need for transition to a higher acuity level of care, increased fraction of inspired oxygen (FiO2), or the initiation of invasive mechanical ventilation. Secondary objectives were to assess the duration of effect of prone positioning on respiratory parameters such as respiratory rate and SpO2, as well as other outcomes such as time to discharge or transition in level of care.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Contemp Clin Trials

DOI

EISSN

1559-2030

Publication Date

October 2021

Volume

109

Start / End Page

106541

Location

United States

Related Subject Headings

  • SARS-CoV-2
  • Respiration, Artificial
  • Public Health
  • Prone Position
  • Patient Positioning
  • Humans
  • General Clinical Medicine
  • COVID-19
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Friedman, E., Franzone, J., Ko, E. R., Corey, K., Mock, J., Alavian, N., … Punjabi, N. M. (2021). Rationale and design of the Prone Position and Respiratory Outcomes in Non-intubated COVID-19 PatiEnts: The "PRONE" Study. Contemp Clin Trials, 109, 106541. https://doi.org/10.1016/j.cct.2021.106541
Friedman, Eugene, John Franzone, Emily R. Ko, Kristin Corey, Jason Mock, Naseem Alavian, Adam Schwartz, et al. “Rationale and design of the Prone Position and Respiratory Outcomes in Non-intubated COVID-19 PatiEnts: The "PRONE" Study.Contemp Clin Trials 109 (October 2021): 106541. https://doi.org/10.1016/j.cct.2021.106541.
Friedman E, Franzone J, Ko ER, Corey K, Mock J, Alavian N, et al. Rationale and design of the Prone Position and Respiratory Outcomes in Non-intubated COVID-19 PatiEnts: The "PRONE" Study. Contemp Clin Trials. 2021 Oct;109:106541.
Friedman, Eugene, et al. “Rationale and design of the Prone Position and Respiratory Outcomes in Non-intubated COVID-19 PatiEnts: The "PRONE" Study.Contemp Clin Trials, vol. 109, Oct. 2021, p. 106541. Pubmed, doi:10.1016/j.cct.2021.106541.
Friedman E, Franzone J, Ko ER, Corey K, Mock J, Alavian N, Schwartz A, Drummond MB, Suber T, Linstrum K, Bain W, Castiblanco SA, Zak M, Zaeh S, Gupta I, Damarla M, Punjabi NM. Rationale and design of the Prone Position and Respiratory Outcomes in Non-intubated COVID-19 PatiEnts: The "PRONE" Study. Contemp Clin Trials. 2021 Oct;109:106541.
Journal cover image

Published In

Contemp Clin Trials

DOI

EISSN

1559-2030

Publication Date

October 2021

Volume

109

Start / End Page

106541

Location

United States

Related Subject Headings

  • SARS-CoV-2
  • Respiration, Artificial
  • Public Health
  • Prone Position
  • Patient Positioning
  • Humans
  • General Clinical Medicine
  • COVID-19
  • 42 Health sciences
  • 32 Biomedical and clinical sciences