Optimal Immunosuppression Strategy in the Sensitized Kidney Transplant Recipient.
Patients with previous sensitization events against anti-human leukocyte antigens (HLA) often have circulating anti-HLA antibodies. Following organ transplantation, sensitized patients have higher rates of antibody-mediated rejection (AMR) compared to those who are non-sensitized. More stringent donor matching is required for these patients, which results in a reduced donor pool and increased time on the waitlist. Current approaches for sensitized patients focus on reducing preformed antibodies that preclude transplantation; however, this type of desensitization does not modulate the primed immune response in sensitized patients. Thus, an optimized maintenance immunosuppressive regimen is necessary for highly sensitized patients, which may be distinct from non-sensitized patients. In this review, we will discuss the currently available therapeutic options for induction, maintenance, and adjuvant immunosuppression for sensitized patients.
Duke Scholars
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- 32 Biomedical and clinical sciences
- 1103 Clinical Sciences
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Published In
DOI
ISSN
Publication Date
Volume
Issue
Location
Related Subject Headings
- 32 Biomedical and clinical sciences
- 1103 Clinical Sciences