How RNA modifications regulate the antiviral response.
Induction of the antiviral innate immune response is highly regulated at the RNA level, particularly by RNA modifications. Recent discoveries have revealed how RNA modifications play key roles in cellular surveillance of nucleic acids and in controlling gene expression in response to viral infection. These modifications have emerged as being essential for a functional antiviral response and maintaining cellular homeostasis. In this review, we will highlight these and other discoveries that describe how the antiviral response is controlled by modifications to both viral and cellular RNA, focusing on how mRNA cap modifications, N6-methyladenosine, and RNA editing all contribute to coordinating an efficient response that properly controls viral infection.
Duke Scholars
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Related Subject Headings
- Virus Diseases
- RNA, Viral
- RNA
- Immunology
- Immunity, Innate
- Humans
- Antiviral Agents
- Adenosine
- 3204 Immunology
- 1107 Immunology
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Virus Diseases
- RNA, Viral
- RNA
- Immunology
- Immunity, Innate
- Humans
- Antiviral Agents
- Adenosine
- 3204 Immunology
- 1107 Immunology