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Gestational Phthalate Exposure and Preschool Attention Deficit Hyperactivity Disorder in Norway.

Publication ,  Journal Article
Kamai, EM; Villanger, GD; Nethery, RC; Thomsen, C; Sakhi, AK; Drover, SSM; Hoppin, JA; Knudsen, GP; Reichborn-Kjennerud, T; Zeiner, P; Aase, H ...
Published in: Environmental epidemiology (Philadelphia, Pa.)
August 2021

Prenatal phthalate exposure has been linked to altered neurobehavioral development in both animal models and epidemiologic studies, but whether or not these associations translate to increased risk of neurodevelopmental disorders is unclear. We used a nested case-cohort study design to assess whether maternal urinary concentrations of 12 phthalate metabolites at 17 weeks gestation were associated with criteria for Attention Deficit Hyperactivity Disorder (ADHD) classified among 3-year-old children in the Norwegian Mother, Father and Child Cohort Study (MoBa). Between 2007 and 2011, 260 children in this substudy were classified with ADHD using a standardized, on-site clinical assessment; they were compared with 549 population-based controls. We modeled phthalate levels both linearly and by quintiles in logistic regression models adjusted for relevant covariates and tested for interaction by child sex. Children of mothers in the highest quintile of di-iso-nonyl phthalate (∑DiNP) metabolite levels had 1.70 times the odds of being classified with ADHD compared with those in the lowest quintile (95% confidence interval [CI] = 1.03 to 2.82). In linear models, there was a trend with the sum of di-2-ethylhexyl phthalate metabolites (∑DEHP); each natural log-unit increase in concentration was associated with 1.22 times the odds of ADHD (95% CI = 0.99 to 1.52). In boys, but not girls, mono-n-butyl phthalate exposure was associated with increased odds of ADHD (odds ratio [OR] 1.42; 95% CI = 1.07 to 1.88). Additional adjustment for correlated phthalate metabolites attenuated estimates. These results suggest gestational phthalate exposure may impact the behavior of children as young as 3 years.

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Published In

Environmental epidemiology (Philadelphia, Pa.)

DOI

EISSN

2474-7882

ISSN

2474-7882

Publication Date

August 2021

Volume

5

Issue

4

Start / End Page

e161
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kamai, E. M., Villanger, G. D., Nethery, R. C., Thomsen, C., Sakhi, A. K., Drover, S. S. M., … Engel, S. M. (2021). Gestational Phthalate Exposure and Preschool Attention Deficit Hyperactivity Disorder in Norway. Environmental Epidemiology (Philadelphia, Pa.), 5(4), e161. https://doi.org/10.1097/ee9.0000000000000161
Kamai, Elizabeth M., Gro D. Villanger, Rachel C. Nethery, Cathrine Thomsen, Amrit K. Sakhi, Samantha S. M. Drover, Jane A. Hoppin, et al. “Gestational Phthalate Exposure and Preschool Attention Deficit Hyperactivity Disorder in Norway.Environmental Epidemiology (Philadelphia, Pa.) 5, no. 4 (August 2021): e161. https://doi.org/10.1097/ee9.0000000000000161.
Kamai EM, Villanger GD, Nethery RC, Thomsen C, Sakhi AK, Drover SSM, et al. Gestational Phthalate Exposure and Preschool Attention Deficit Hyperactivity Disorder in Norway. Environmental epidemiology (Philadelphia, Pa). 2021 Aug;5(4):e161.
Kamai, Elizabeth M., et al. “Gestational Phthalate Exposure and Preschool Attention Deficit Hyperactivity Disorder in Norway.Environmental Epidemiology (Philadelphia, Pa.), vol. 5, no. 4, Aug. 2021, p. e161. Epmc, doi:10.1097/ee9.0000000000000161.
Kamai EM, Villanger GD, Nethery RC, Thomsen C, Sakhi AK, Drover SSM, Hoppin JA, Knudsen GP, Reichborn-Kjennerud T, Zeiner P, Overgaard K, Herring AH, Aase H, Engel SM. Gestational Phthalate Exposure and Preschool Attention Deficit Hyperactivity Disorder in Norway. Environmental epidemiology (Philadelphia, Pa). 2021 Aug;5(4):e161.

Published In

Environmental epidemiology (Philadelphia, Pa.)

DOI

EISSN

2474-7882

ISSN

2474-7882

Publication Date

August 2021

Volume

5

Issue

4

Start / End Page

e161