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The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents.

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Robinson, DL; Amodeo, LR; Chandler, LJ; Crews, FT; Ehlers, CL; Gómez-A, A; Healey, KL; Kuhn, CM; Macht, VA; Marshall, SA; Swartzwelder, HS ...
2021

Alcohol drinking is often initiated during adolescence, and this frequently escalates to binge drinking. As adolescence is also a period of dynamic neurodevelopment, preclinical evidence has highlighted that some of the consequences of binge drinking can be long lasting with deficits persisting into adulthood in a variety of cognitive-behavioral tasks. However, while the majority of preclinical work to date has been performed in male rodents, the rapid increase in binge drinking in adolescent female humans has re-emphasized the importance of addressing alcohol effects in the context of sex as a biological variable. Here we review several of the consequences of adolescent ethanol exposure in light of sex as a critical biological variable. While some alcohol-induced outcomes, such as non-social approach/avoidance behavior and sleep disruption, are generally consistent across sex, others are variable across sex, such as alcohol drinking, sensitivity to ethanol, social anxiety-like behavior, and induction of proinflammatory markers.

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DOI

Publication Date

2021

Volume

160

Start / End Page

305 / 340

Related Subject Headings

  • Sex Factors
  • Rodentia
  • Neurology & Neurosurgery
  • Male
  • Female
  • Ethanol
  • Behavior, Animal
  • Animals
  • Alcohol Drinking
  • 5202 Biological psychology
 

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Robinson, D. L., Amodeo, L. R., Chandler, L. J., Crews, F. T., Ehlers, C. L., Gómez-A, A., … Werner, D. F. (2021). The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents. (Vol. 160, pp. 305–340). https://doi.org/10.1016/bs.irn.2021.07.007
Robinson, Donita L., Leslie R. Amodeo, L Judson Chandler, Fulton T. Crews, Cindy L. Ehlers, Alexander Gómez-A, Kati L. Healey, et al. “The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents.,” 160:305–40, 2021. https://doi.org/10.1016/bs.irn.2021.07.007.
Robinson DL, Amodeo LR, Chandler LJ, Crews FT, Ehlers CL, Gómez-A A, et al. The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents. In 2021. p. 305–40.
Robinson, Donita L., et al. The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents. Vol. 160, 2021, pp. 305–40. Pubmed, doi:10.1016/bs.irn.2021.07.007.
Robinson DL, Amodeo LR, Chandler LJ, Crews FT, Ehlers CL, Gómez-A A, Healey KL, Kuhn CM, Macht VA, Marshall SA, Swartzwelder HS, Varlinskaya EI, Werner DF. The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents. 2021. p. 305–340.

DOI

Publication Date

2021

Volume

160

Start / End Page

305 / 340

Related Subject Headings

  • Sex Factors
  • Rodentia
  • Neurology & Neurosurgery
  • Male
  • Female
  • Ethanol
  • Behavior, Animal
  • Animals
  • Alcohol Drinking
  • 5202 Biological psychology