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Assessment of primary prevention patients receiving an ICD - Systematic evaluation of ATP: APPRAISE ATP.

Publication ,  Journal Article
Schuger, CD; Ando, K; Cantillon, DJ; Lambiase, PD; Mont, L; Joung, BY; Peress, D; Yong, P; Wold, N; Daubert, JP
Published in: Heart Rhythm O2
August 2021

BACKGROUND: The value of antitachycardia pacing (ATP) in the overall cohort of primary prevention patients who receive implantable cardioverter-defibrillators (ICDs) remains uncertain. ATP success reported in prior trials potentially included a large number of patients receiving unnecessary ATP for arrhythmias that may have self-terminated owing to the prematurity of the intervention. Although some patients derive benefit from initial ATP in terminating rapid ventricular arrhythmias and thereby preventing shocks, there are limited data allowing us to identify those patients a priori. OBJECTIVE: The purpose of APPRAISE ATP is to understand the role of ATP in primary prevention patients currently indicated for ICD therapy in a large prospective randomized controlled trial with modern programming parameters. METHODS: The study is a global, prospective, randomized, multicenter clinical trial conducted at up to 150 sites globally, enrolling approximately 2600 subjects The primary endpoint of the trial is time to first all-cause shock in a 2-arm study with an equivalent study design in which the incidence of all-cause shocks will be compared between primary prevention subjects programmed with shocks only vs subjects programmed to standard therapy (ATP and shock). RESULTS: An Electrogram and Device Interrogation Core Laboratory will review interrogation data to determine primary endpoints that occur in APPRAISE ATP. Their decisions are based on independent physician review of the data from device interrogation. CONCLUSION: The ultimate purpose of the study is to aid clinicians in the selection of ICD technologies based on hard endpoint evidence across the spectrum of indications for primary prevention implantation.

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Published In

Heart Rhythm O2

DOI

EISSN

2666-5018

Publication Date

August 2021

Volume

2

Issue

4

Start / End Page

405 / 411

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
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Schuger, C. D., Ando, K., Cantillon, D. J., Lambiase, P. D., Mont, L., Joung, B. Y., … Daubert, J. P. (2021). Assessment of primary prevention patients receiving an ICD - Systematic evaluation of ATP: APPRAISE ATP. Heart Rhythm O2, 2(4), 405–411. https://doi.org/10.1016/j.hroo.2021.07.003
Schuger, Claudio D., Kenji Ando, Daniel J. Cantillon, Pier D. Lambiase, Lluis Mont, Bo Young Joung, Darren Peress, Patrick Yong, Nicholas Wold, and James P. Daubert. “Assessment of primary prevention patients receiving an ICD - Systematic evaluation of ATP: APPRAISE ATP.Heart Rhythm O2 2, no. 4 (August 2021): 405–11. https://doi.org/10.1016/j.hroo.2021.07.003.
Schuger CD, Ando K, Cantillon DJ, Lambiase PD, Mont L, Joung BY, et al. Assessment of primary prevention patients receiving an ICD - Systematic evaluation of ATP: APPRAISE ATP. Heart Rhythm O2. 2021 Aug;2(4):405–11.
Schuger, Claudio D., et al. “Assessment of primary prevention patients receiving an ICD - Systematic evaluation of ATP: APPRAISE ATP.Heart Rhythm O2, vol. 2, no. 4, Aug. 2021, pp. 405–11. Pubmed, doi:10.1016/j.hroo.2021.07.003.
Schuger CD, Ando K, Cantillon DJ, Lambiase PD, Mont L, Joung BY, Peress D, Yong P, Wold N, Daubert JP. Assessment of primary prevention patients receiving an ICD - Systematic evaluation of ATP: APPRAISE ATP. Heart Rhythm O2. 2021 Aug;2(4):405–411.

Published In

Heart Rhythm O2

DOI

EISSN

2666-5018

Publication Date

August 2021

Volume

2

Issue

4

Start / End Page

405 / 411

Location

United States