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Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees

Publication ,  Journal Article
Ertekin-Taner, N; Graff-Radford, N; Younkin, LH; Eckman, C; Baker, M; Adamson, J; Ronald, J; Blangero, J; Hutton, M; Younkin, SG
Published in: Science
December 22, 2000

Plasma Aβ42 (amyloid β42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Aβ42, we used plasma Aβ42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Aβ. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Aβ.

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Published In

Science

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

December 22, 2000

Volume

290

Issue

5500

Start / End Page

2303 / 2304

Publisher

American Association for the Advancement of Science (AAAS)

Related Subject Headings

  • General Science & Technology
 

Citation

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Chicago
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Ertekin-Taner, N., Graff-Radford, N., Younkin, L. H., Eckman, C., Baker, M., Adamson, J., … Younkin, S. G. (2000). Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees. Science, 290(5500), 2303–2304. https://doi.org/10.1126/science.290.5500.2303
Ertekin-Taner, Nilufer, Neill Graff-Radford, Linda H. Younkin, Christopher Eckman, Matthew Baker, Jennifer Adamson, James Ronald, John Blangero, Michael Hutton, and Steven G. Younkin. “Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees.” Science 290, no. 5500 (December 22, 2000): 2303–4. https://doi.org/10.1126/science.290.5500.2303.
Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Baker M, Adamson J, et al. Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees. Science. 2000 Dec 22;290(5500):2303–4.
Ertekin-Taner, Nilufer, et al. “Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees.” Science, vol. 290, no. 5500, American Association for the Advancement of Science (AAAS), Dec. 2000, pp. 2303–04. Crossref, doi:10.1126/science.290.5500.2303.
Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Baker M, Adamson J, Ronald J, Blangero J, Hutton M, Younkin SG. Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees. Science. American Association for the Advancement of Science (AAAS); 2000 Dec 22;290(5500):2303–2304.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

December 22, 2000

Volume

290

Issue

5500

Start / End Page

2303 / 2304

Publisher

American Association for the Advancement of Science (AAAS)

Related Subject Headings

  • General Science & Technology