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Effect of tumor size on drug delivery to lung tumors

Publication ,  Conference
Soltani, M; Sefidgar, M; Bazmara, H; Marcus, C; Subramaniam, RM; Rahmim, A
Published in: 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015
October 3, 2016

Drug delivery to solid tumors can be expressed physically using biomechanical phenomena such as convection, diffusion of drug in extracellular matrices, and drug extravasation from microvessels. Applying computational methods to solve governing conservation equations clarifies the mechanisms of drug delivery from the injection site to a solid tumor. In this study, multiple tumor geometries were obtained from PET/CT images. An advanced numerical method was used to solve fluid flow and solute transport equations simultaneously to investigate the effect of tumor size on drug delivery to lung tumors. Data from 20 patients with lung tumors were analyzed and the tumor geometrical information including size, shape, and aspect ratios were classified. In order to investigate effect of tumor size, tumors with similar shapes but different sizes ranging from 1 to 28.6 cm3 were selected and analyzed. A hypothetical tumor, similar to one of the analyzed tumors but scaled to reduce its size to 0.2 cm3, was also analyzed. An ideal bolus injection was considered for the model. The effects of two transport mechanisms, namely convection and diffusion, were considered in this study. The results show because of size of considered lung tumor, the diffusion transport rate is higher than convection transport rate. Based on governing equations, the diffusion transport is only depended on concentration gradient and independent of size of tumor, therefore the predicted concentration profile for considered tumors are similar. When size of tumor is decreased significantly, the drug concentration is also significantly increased.

Duke Scholars

Published In

2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015

DOI

ISBN

9781467398626

Publication Date

October 3, 2016
 

Citation

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Soltani, M., Sefidgar, M., Bazmara, H., Marcus, C., Subramaniam, R. M., & Rahmim, A. (2016). Effect of tumor size on drug delivery to lung tumors. In 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. https://doi.org/10.1109/NSSMIC.2015.7582238
Soltani, M., M. Sefidgar, H. Bazmara, C. Marcus, R. M. Subramaniam, and A. Rahmim. “Effect of tumor size on drug delivery to lung tumors.” In 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015, 2016. https://doi.org/10.1109/NSSMIC.2015.7582238.
Soltani M, Sefidgar M, Bazmara H, Marcus C, Subramaniam RM, Rahmim A. Effect of tumor size on drug delivery to lung tumors. In: 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. 2016.
Soltani, M., et al. “Effect of tumor size on drug delivery to lung tumors.” 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015, 2016. Scopus, doi:10.1109/NSSMIC.2015.7582238.
Soltani M, Sefidgar M, Bazmara H, Marcus C, Subramaniam RM, Rahmim A. Effect of tumor size on drug delivery to lung tumors. 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. 2016.

Published In

2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015

DOI

ISBN

9781467398626

Publication Date

October 3, 2016