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18F-FDG PET/CT and Melanoma: Value of Fourth and Subsequent Posttherapy Follow-up Scans for Patient Management.

Publication ,  Journal Article
Mena, E; Taghipour, M; Sheikhbahaei, S; Mirpour, S; Xiao, J; Subramaniam, RM
Published in: Clin Nucl Med
September 2016

PURPOSE: We aimed to evaluate the added value of performing fourth and subsequent follow-up F-FDG-PET/CT scans to clinical assessment and impact on the patient's management in patients with melanoma. METHODS: This was a retrospective study of 232 biopsy-proven melanoma patients who underwent F-FDG-PET/CT scans. Of these, 71 patients had 4 or more follow-up F-FDG-PET/CT scans after completion of primary treatment, with a total of 246 fourth or subsequent follow-up PET/CT scans. The added value of each follow-up PET/CT scan to the patient's clinical assessment and treatment management was established. Kaplan-Meier plots with a Mantel-Cox log-rank test were used to establish the patient's overall survival. RESULTS: Of the 246 fourth and subsequent follow-up PET/CT scans, 61% (150/246) were negative for malignancy, and 39.0% (96/246) were positive for recurrence/metastases. FDG-PET/CT was helpful in identifying malignancy in 6.5% of the scans performed without prior clinical suspicion, which ruled out malignancy in 28.5% of the scans obtained with prior clinical signs suggestive of recurrence or for secondary therapy assessment. The PET/CT scan resulted in change of the patient's management in approximately 16.7% (41/246) of the scans. Change in management was significantly greater in patients whose scans were done with prior clinical signs suggestive of malignancy, or for therapy assessment than without prior clinical suspicion (29.3% vs 4.1%; P < 0.0001). Statistically significant difference was seen in the overall survival between patients with at least 1 positive and all negative fourth and subsequent follow-up PET/CT scans at patient level (P = 0.001). CONCLUSIONS: The fourth and subsequent F-FDG-PET/CT scans obtained after completion of primary treatment added value to clinical assessment in patients with melanoma. Patients with clinical signs suggestive of recurrence or metastases or being monitored for treatment response are more likely to benefit from the fourth or subsequent FDG PET/CT than those without prior clinical suspicion.

Duke Scholars

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Published In

Clin Nucl Med

DOI

EISSN

1536-0229

Publication Date

September 2016

Volume

41

Issue

9

Start / End Page

e403 / e409

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Retrospective Studies
  • Radiopharmaceuticals
  • Positron Emission Tomography Computed Tomography
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Melanoma
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mena, E., Taghipour, M., Sheikhbahaei, S., Mirpour, S., Xiao, J., & Subramaniam, R. M. (2016). 18F-FDG PET/CT and Melanoma: Value of Fourth and Subsequent Posttherapy Follow-up Scans for Patient Management. Clin Nucl Med, 41(9), e403–e409. https://doi.org/10.1097/RLU.0000000000001275
Mena, Esther, Mehdi Taghipour, Sara Sheikhbahaei, Sahar Mirpour, Jennifer Xiao, and Rathan M. Subramaniam. “18F-FDG PET/CT and Melanoma: Value of Fourth and Subsequent Posttherapy Follow-up Scans for Patient Management.Clin Nucl Med 41, no. 9 (September 2016): e403–9. https://doi.org/10.1097/RLU.0000000000001275.
Mena E, Taghipour M, Sheikhbahaei S, Mirpour S, Xiao J, Subramaniam RM. 18F-FDG PET/CT and Melanoma: Value of Fourth and Subsequent Posttherapy Follow-up Scans for Patient Management. Clin Nucl Med. 2016 Sep;41(9):e403–9.
Mena, Esther, et al. “18F-FDG PET/CT and Melanoma: Value of Fourth and Subsequent Posttherapy Follow-up Scans for Patient Management.Clin Nucl Med, vol. 41, no. 9, Sept. 2016, pp. e403–09. Pubmed, doi:10.1097/RLU.0000000000001275.
Mena E, Taghipour M, Sheikhbahaei S, Mirpour S, Xiao J, Subramaniam RM. 18F-FDG PET/CT and Melanoma: Value of Fourth and Subsequent Posttherapy Follow-up Scans for Patient Management. Clin Nucl Med. 2016 Sep;41(9):e403–e409.

Published In

Clin Nucl Med

DOI

EISSN

1536-0229

Publication Date

September 2016

Volume

41

Issue

9

Start / End Page

e403 / e409

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Retrospective Studies
  • Radiopharmaceuticals
  • Positron Emission Tomography Computed Tomography
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Melanoma
  • Male
  • Humans