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FDG volumetric parameters and survival outcomes after definitive chemoradiotherapy in patients with recurrent head and neck squamous cell carcinoma.

Publication ,  Journal Article
Paidpally, V; Chirindel, A; Chung, CH; Richmon, J; Koch, W; Quon, H; Subramaniam, RM
Published in: AJR Am J Roentgenol
August 2014

OBJECTIVE: The purpose of this study was to establish the predictive value of (18)F-FDG parameters for overall survival in biopsy-proven recurrent head and neck squamous cell cancer (HNSCC) patients after definitive chemoradiotherapy. MATERIALS AND METHODS: We conducted a retrospective study including 34 patients with HNSCC who had biopsy-proven recurrence between April 2004 and March 2012 and underwent FDG PET/CT at our institution at the time of recurrence. Maximum standardized uptake value (SUVmax), peak SUV (SUVpeak), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured. The primary outcome measure was overall survival. ROC analysis, univariate and multivariate Cox regression models, and Kaplan-Meir survival curves were performed. RESULTS: In univariate analyses, human papillomavirus (HPV) status (p = 0.04), primary site recurrence of MTV (p = 0.03), metastasis of MTV (p = 0.02), metastasis of TLG (p = 0.02), total MTV (p = 0.002), and total TLG (p = 0.04) were significantly associated with overall survival outcome. Total MTV remained as significant independent prognostic factor when adjusted for all other covariates except for primary site recurrence SUVmax and SUVpeak and lymph node SUVmax and SUVpeak. There was a significant difference in time to survival between patients with total MTV above and below the 50th percentile (Mantel-Cox log-rank test, p = 0.05 and Gehan-Breslow-Wilcoxon test, p = 0.03) and the optimum threshold of 16.8 mL (Mantel-Cox log-rank test, p = 0.01 and Gehan-Breslow-Wilcoxon test, p = 0.01; hazard ratio [HR], 0.25). CONCLUSION: FDG PET/CT-based total MTV and clinical HPV status may be significant prognostic markers for overall survival of patients with recurrent HNSCC after definitive chemoradiotherapy.

Duke Scholars

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

August 2014

Volume

203

Issue

2

Start / End Page

W139 / W145

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Survival Rate
  • Retrospective Studies
  • Radiopharmaceuticals
  • Prognosis
  • Predictive Value of Tests
  • Positron-Emission Tomography
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Recurrence, Local
  • Multimodal Imaging
 

Citation

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ICMJE
MLA
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Paidpally, V., Chirindel, A., Chung, C. H., Richmon, J., Koch, W., Quon, H., & Subramaniam, R. M. (2014). FDG volumetric parameters and survival outcomes after definitive chemoradiotherapy in patients with recurrent head and neck squamous cell carcinoma. AJR Am J Roentgenol, 203(2), W139–W145. https://doi.org/10.2214/AJR.13.11654
Paidpally, Vasavi, Alin Chirindel, Christine H. Chung, Jeremy Richmon, Wayne Koch, Harry Quon, and Rathan M. Subramaniam. “FDG volumetric parameters and survival outcomes after definitive chemoradiotherapy in patients with recurrent head and neck squamous cell carcinoma.AJR Am J Roentgenol 203, no. 2 (August 2014): W139–45. https://doi.org/10.2214/AJR.13.11654.
Paidpally V, Chirindel A, Chung CH, Richmon J, Koch W, Quon H, et al. FDG volumetric parameters and survival outcomes after definitive chemoradiotherapy in patients with recurrent head and neck squamous cell carcinoma. AJR Am J Roentgenol. 2014 Aug;203(2):W139–45.
Paidpally, Vasavi, et al. “FDG volumetric parameters and survival outcomes after definitive chemoradiotherapy in patients with recurrent head and neck squamous cell carcinoma.AJR Am J Roentgenol, vol. 203, no. 2, Aug. 2014, pp. W139–45. Pubmed, doi:10.2214/AJR.13.11654.
Paidpally V, Chirindel A, Chung CH, Richmon J, Koch W, Quon H, Subramaniam RM. FDG volumetric parameters and survival outcomes after definitive chemoradiotherapy in patients with recurrent head and neck squamous cell carcinoma. AJR Am J Roentgenol. 2014 Aug;203(2):W139–W145.

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

August 2014

Volume

203

Issue

2

Start / End Page

W139 / W145

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Survival Rate
  • Retrospective Studies
  • Radiopharmaceuticals
  • Prognosis
  • Predictive Value of Tests
  • Positron-Emission Tomography
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Recurrence, Local
  • Multimodal Imaging