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Preoperative predictors of pathological lymph node metastasis in patients with renal cell carcinoma undergoing retroperitoneal lymph node dissection.

Publication ,  Journal Article
Babaian, KN; Kim, DY; Kenney, PA; Wood, CG; Wong, J; Sanchez, C; Fang, JE; Gerber, JA; Didic, A; Wahab, A; Golla, V; Torres, C; Tamboli, P ...
Published in: J Urol
April 2015

PURPOSE: Patients with locally advanced renal cell carcinoma represent a subset that may benefit from retroperitoneal lymph node dissection. We identified preoperative clinical predictors of positive lymph nodes in patients with renal cell carcinoma without distant metastasis who underwent retroperitoneal lymph node dissection. MATERIALS AND METHODS: We retrospectively analyzed data on a consecutive cohort of 1,270 patients with cTany Nany M0 renal cell carcinoma who were treated at a single institution from 1993 to 2012. Multivariate analysis was performed to determine preoperative predictors of pathologically positive lymph nodes in patients who underwent retroperitoneal lymph node dissection. A nomogram was developed to predict the probability of lymph node metastasis. Overall, cancer specific and recurrence-free survival was estimated using the Kaplan-Meier Method. RESULTS: We identified 1,270 patients with renal cell carcinoma without distant metastasis who had (564) or did not have (706) retroperitoneal lymph node dissection performed. Of the 564 patients 131 (23%) and 433 (77%) had pN1 and pN0 disease, and 60 (37%) and 29 (7.2%) had cN1pN0 and cN0pN1 disease, respectively. ECOG PS, cN stage, local symptoms and lactate dehydrogenase were associated with nodal metastasis on multivariable analysis. A nomogram was developed with a C-index of 0.89 that demonstrated excellent calibration. Differences in overall, cancer specific and recurrence-free survival among pNx, pN0 and pN1 cases were statistically significant (p <0.001). CONCLUSIONS: Local symptoms, ECOG PS, cN stage and lactate dehydrogenase were independent predictors of lymph node metastasis in patients who underwent retroperitoneal lymph node dissection. Our predictive nomogram using these factors showed excellent discrimination and calibration.

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Published In

J Urol

DOI

EISSN

1527-3792

Publication Date

April 2015

Volume

193

Issue

4

Start / End Page

1101 / 1107

Location

United States

Related Subject Headings

  • Young Adult
  • Urology & Nephrology
  • Retrospective Studies
  • Retroperitoneal Space
  • Prognosis
  • Preoperative Period
  • Nomograms
  • Middle Aged
  • Male
  • Lymphatic Metastasis
 

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Babaian, K. N., Kim, D. Y., Kenney, P. A., Wood, C. G., Wong, J., Sanchez, C., … Karam, J. A. (2015). Preoperative predictors of pathological lymph node metastasis in patients with renal cell carcinoma undergoing retroperitoneal lymph node dissection. J Urol, 193(4), 1101–1107. https://doi.org/10.1016/j.juro.2014.10.096
Babaian, Kara N., Dae Y. Kim, Patrick A. Kenney, Christopher G. Wood, Joseph Wong, Christopher Sanchez, Justin E. Fang, et al. “Preoperative predictors of pathological lymph node metastasis in patients with renal cell carcinoma undergoing retroperitoneal lymph node dissection.J Urol 193, no. 4 (April 2015): 1101–7. https://doi.org/10.1016/j.juro.2014.10.096.
Babaian KN, Kim DY, Kenney PA, Wood CG, Wong J, Sanchez C, et al. Preoperative predictors of pathological lymph node metastasis in patients with renal cell carcinoma undergoing retroperitoneal lymph node dissection. J Urol. 2015 Apr;193(4):1101–7.
Babaian, Kara N., et al. “Preoperative predictors of pathological lymph node metastasis in patients with renal cell carcinoma undergoing retroperitoneal lymph node dissection.J Urol, vol. 193, no. 4, Apr. 2015, pp. 1101–07. Pubmed, doi:10.1016/j.juro.2014.10.096.
Babaian KN, Kim DY, Kenney PA, Wood CG, Wong J, Sanchez C, Fang JE, Gerber JA, Didic A, Wahab A, Golla V, Torres C, Tamboli P, Qiao W, Matin SF, Karam JA. Preoperative predictors of pathological lymph node metastasis in patients with renal cell carcinoma undergoing retroperitoneal lymph node dissection. J Urol. 2015 Apr;193(4):1101–1107.
Journal cover image

Published In

J Urol

DOI

EISSN

1527-3792

Publication Date

April 2015

Volume

193

Issue

4

Start / End Page

1101 / 1107

Location

United States

Related Subject Headings

  • Young Adult
  • Urology & Nephrology
  • Retrospective Studies
  • Retroperitoneal Space
  • Prognosis
  • Preoperative Period
  • Nomograms
  • Middle Aged
  • Male
  • Lymphatic Metastasis