Skip to main content
Journal cover image
Molecular Genetics of Dysregulated pH Homeostasis

A genomic analysis of cellular responses and adaptions to extracellular acidosis

Publication ,  Chapter
Keenan, MM; Lin, CC; Ashley Chi, JT
January 1, 2014

Even though lactic acidosis is a prominent feature of solid tumors, we have limited understanding of the mechanisms by which lactic acidosis influences the genetic, epigenetic, proteomic, and metabolic phenotypes of cancer cells. This chapter aims to (1) briefly outline the tumor microenvironment and how acidity relates to its biology; (2) briefly discuss traditional hypothesis-driven or single-gene studies that have explored cancer cells’ responses to acidosis or lactic acidosis; (3) explain what we have learned from “-omics” approaches that have been applied to studying cellular response to acid and lactic acid; and (4) reflect on the projections of these studies in (2) and (3) to in vivo human tumor biology and how we can use this information to better inform disease treatments.

Duke Scholars

DOI

ISBN

9781493916825

Publication Date

January 1, 2014

Start / End Page

135 / 157
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Keenan, M. M., Lin, C. C., & Ashley Chi, J. T. (2014). A genomic analysis of cellular responses and adaptions to extracellular acidosis. In Molecular Genetics of Dysregulated pH Homeostasis (pp. 135–157). https://doi.org/10.1007/978-1-4939-1683-2_8
Keenan, M. M., C. C. Lin, and J. T. Ashley Chi. “A genomic analysis of cellular responses and adaptions to extracellular acidosis.” In Molecular Genetics of Dysregulated PH Homeostasis, 135–57, 2014. https://doi.org/10.1007/978-1-4939-1683-2_8.
Keenan MM, Lin CC, Ashley Chi JT. A genomic analysis of cellular responses and adaptions to extracellular acidosis. In: Molecular Genetics of Dysregulated pH Homeostasis. 2014. p. 135–57.
Keenan, M. M., et al. “A genomic analysis of cellular responses and adaptions to extracellular acidosis.” Molecular Genetics of Dysregulated PH Homeostasis, 2014, pp. 135–57. Scopus, doi:10.1007/978-1-4939-1683-2_8.
Keenan MM, Lin CC, Ashley Chi JT. A genomic analysis of cellular responses and adaptions to extracellular acidosis. Molecular Genetics of Dysregulated pH Homeostasis. 2014. p. 135–157.
Journal cover image

DOI

ISBN

9781493916825

Publication Date

January 1, 2014

Start / End Page

135 / 157