Skip to main content

Association between Kidney Function, Proteinuria and the Risk of Multiple Myeloma: A Population-Based Retrospective Cohort Study in South Korea.

Publication ,  Journal Article
Choi, T; Ahn, W; Shin, DW; Han, K; Kim, D; Chun, S
Published in: Cancer Res Treat
July 2022

PURPOSE: While renal impairment is one of the first clinical manifestations of multiple myeloma (MM), declined renal function may conversely be a risk factor for cancers including MM. In this study, we investigated the relationship between chronic kidney disease and MM at a population level. MATERIALS AND METHODS: A total of 9,809,376 adults who participated in a nationwide health screening program and had no MM, cancer or end-stage renal disease at baseline were investigated for incidence of MM. The impact of estimated glomerular filtration rate (eGFR) and random urine dipstick proteinuria, and interactive associations of the two factors on the MM incidence were evaluated. RESULTS: The general incidence of MM was 4.8 per 100,000 person-years (mean follow-up of 8.3 years). Participants with eGFR < 60 mL/min/1.73 m2 (5.8% of participants) had higher MM incidence than those with eGFR ≥ 60 mL/min/1.73 m2 (adjusted hazard ratio, 1.29; 95% confidence interval, 1.17 to 1.43). When eGFR was graded into five levels, there was a significant inverse dose-response relationship between eGFR level and MM incidence at the lower eGFR levels (reference: eGFR 60-89 mL/min/1.73 m2). A dose-response relationship was also found with degree of dipstick proteinuria and incidence of MM. CONCLUSION: Adults with decreased renal function indicated either by decreased eGFR or presence of proteinuria are at a higher risk of developing MM compared to those without, and there is a dose-response relationship between the severity of renal impairment and MM incidence.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer Res Treat

DOI

EISSN

2005-9256

Publication Date

July 2022

Volume

54

Issue

3

Start / End Page

926 / 936

Location

Korea (South)

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Republic of Korea
  • Proteinuria
  • Multiple Myeloma
  • Kidney
  • Humans
  • Cohort Studies
  • Adult
  • 3211 Oncology and carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Choi, T., Ahn, W., Shin, D. W., Han, K., Kim, D., & Chun, S. (2022). Association between Kidney Function, Proteinuria and the Risk of Multiple Myeloma: A Population-Based Retrospective Cohort Study in South Korea. Cancer Res Treat, 54(3), 926–936. https://doi.org/10.4143/crt.2021.951
Choi, Taewoong, Wooin Ahn, Dong Wook Shin, Kyungdo Han, Dahye Kim, and Sohyun Chun. “Association between Kidney Function, Proteinuria and the Risk of Multiple Myeloma: A Population-Based Retrospective Cohort Study in South Korea.Cancer Res Treat 54, no. 3 (July 2022): 926–36. https://doi.org/10.4143/crt.2021.951.
Choi, Taewoong, et al. “Association between Kidney Function, Proteinuria and the Risk of Multiple Myeloma: A Population-Based Retrospective Cohort Study in South Korea.Cancer Res Treat, vol. 54, no. 3, July 2022, pp. 926–36. Pubmed, doi:10.4143/crt.2021.951.

Published In

Cancer Res Treat

DOI

EISSN

2005-9256

Publication Date

July 2022

Volume

54

Issue

3

Start / End Page

926 / 936

Location

Korea (South)

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Republic of Korea
  • Proteinuria
  • Multiple Myeloma
  • Kidney
  • Humans
  • Cohort Studies
  • Adult
  • 3211 Oncology and carcinogenesis