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TNF, cell death and inflammation

Publication ,  Journal Article
Bixby, J; Ray, TD; Chan, FKM
Published in: Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents
January 1, 2005

Tumor necrosis factor (TNFα) is a pleiotropic cytokine that mediates diverse biological responses. In the immune system, TNFα facilitates many aspects of immune responses against pathogenic challenges. While TNFα plays a critical role in the immune defense against pathogens, hyper-activation of the TNFα signaling cascade often results in the development of inflammatory and autoimmune diseases. Examination of natural mutations in human and experimental mouse models that affect TNFα-TNF receptor interaction or their downstream signaling components confirm the importance of this cytokine /receptor pair in the inflammatory process and immunity. Blockade of TNF-TNF receptor interaction has been highly successful in treating several autoimmune diseases including rheumatoid arthritis and Crohn's disease. The pro-inflammatory effects of TNFα can be achieved through several distinct signaling mechanisms including the activation of NF-κB and programmed cell death. In this review, we discuss recent advances in our understanding of the mechanisms by which TNFα induces different forms of programmed cell death and the role they play in mediating the inflammatory response. Specifically, we discuss how the induction of a recently defined cell death pathway, programmed necrosis, by TNFα may contribute to the activation of innate immune responses and the inflammatory process. © 2005 Bentham Science Publishers Ltd.

Duke Scholars

Published In

Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents

DOI

ISSN

1568-0142

Publication Date

January 1, 2005

Volume

4

Issue

6

Start / End Page

557 / 567

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
 

Citation

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Bixby, J., Ray, T. D., & Chan, F. K. M. (2005). TNF, cell death and inflammation. Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents, 4(6), 557–567. https://doi.org/10.2174/156801405774933214
Bixby, J., T. D. Ray, and F. K. M. Chan. “TNF, cell death and inflammation.” Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents 4, no. 6 (January 1, 2005): 557–67. https://doi.org/10.2174/156801405774933214.
Bixby J, Ray TD, Chan FKM. TNF, cell death and inflammation. Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents. 2005 Jan 1;4(6):557–67.
Bixby, J., et al. “TNF, cell death and inflammation.” Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents, vol. 4, no. 6, Jan. 2005, pp. 557–67. Scopus, doi:10.2174/156801405774933214.
Bixby J, Ray TD, Chan FKM. TNF, cell death and inflammation. Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents. 2005 Jan 1;4(6):557–567.

Published In

Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents

DOI

ISSN

1568-0142

Publication Date

January 1, 2005

Volume

4

Issue

6

Start / End Page

557 / 567

Related Subject Headings

  • Medicinal & Biomolecular Chemistry